Thymalin in a 97-patient Lipetsk schizophrenia comparison
A. P. Muzychenko, S. N. Dmitrenkov · 1998 · Affective and Schizoaffective Psychoses. Conference proceedings, 7–8 April 1998.
Reported findings and study design
The authors studied 97 patients with resistant affective or affective-delusional symptoms at Lipetsk Regional Psychoneurological Hospital No. 1. Groups received Thymalin (27), levamisole (17), prodigiosan (13), laser treatment (22) or psychotropic medication alone (18). Participants in the adjunctive groups had not improved substantially after at least three months of prior treatment.
Dose, route and schedule
Thymalin 30 mg intramuscularly daily for 15 days. Levamisole 150 mg orally on four days per week for three weeks. Psychotropic doses were kept fixed during adjunctive treatment. These are historical study methods.
Protocol source ↗ · Original conference methods
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Improvement reported with Thymalin | 25–80% across symptom categories | 27 patients received Thymalin. The report gives no arm-wide response rate. |
| Improvement with psychotropic medication alone | 10–20% across symptom categories | 18 patients in the control group. |
| Improvement reported with levamisole | 20–50% across symptom categories | 17 patients received levamisole. |
| Other reported improvement figures | 50% with prodigiosan and 25–90% with laser treatment | 13 and 22 patients, respectively. The report gives no subgroup counts for these figures. |
| Immunological predictors of response | The authors found no clear immunological predictor of improvement. |
Response figures differ by symptom category. The report supplies no direct significance test, and none of the groups received Imunofan.
Source for these results ↗ · Reviewed 2026-11-10
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The short report gives no randomization or masking details, precise response definition, category-specific denominators, uncertainty estimates or systematic harms.
- The earlier Lipetsk report cannot verify the three-arm comparison cited in 2002. Participant overlap with the later publication is unknown.
Source access
Original conference contribution on the Mental Health Research Centre website. Author initials follow the online text.
Source reviewed 2026-11-10.
Source type: Original conference report, institute-hosted text
Citation and original source
Original source: A. P. Muzychenko, S. N. Dmitrenkov. Thymalin in a 97-patient Lipetsk schizophrenia comparison Affective and Schizoaffective Psychoses. Conference proceedings, 7–8 April 1998. 1998.
Molekul research summary: https://molekul.io/research/muzychenko-thymalin-lipetsk-1998. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry