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Structural and functional changes in the retina of patients with primary open-angle glaucoma and compensated intraocular pressure while undergoing retinoprotective therapy

Egorov EA, Erichev VP, Strakhov VV, Petrov SY, Romanova TB, Vasina MV, Zinina VS, Makarova AS, Kazanova SY, Yartsev AV · 2019 · Vestnik Oftalmologii. 2019;135(3):20–30.

Randomized trialEnglish abstractSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

Study findings

Visual-field indices improved within the treated group while declining in controls. Visual acuity did not change; retinal nerve-fiber thickness and neuroretinal-rim volume remained stable in both groups. Electrophysiological results varied by measure.

Population and setting: 180 glaucoma patients (355 eyes), randomized equally; 12 months
Evidence type: Randomized trial
Preparation: Retinalamin tissue-derived preparation
Source language: English abstract; original language varies
Title source: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

Study limitations

Baseline visual-field values differed. Within-group trends alone do not quantify a between-group treatment effect.
Blinding, multiple testing and handling of correlated eyes require full-methods appraisal.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Source access and review scope

PubMed-indexed abstract and bibliographic metadata checked via Europe PMC; full methods not appraised.

Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.

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DOI: 10.17116/oftalma201913503120

Citation and original source

Original source: Egorov EA, Erichev VP, Strakhov VV, Petrov SY, Romanova TB, Vasina MV, Zinina VS, Makarova AS, Kazanova SY, Yartsev AV. Structural and functional changes in the retina of patients with primary open-angle glaucoma and compensated intraocular pressure while undergoing retinoprotective therapy Vestnik Oftalmologii. 2019;135(3):20–30. 2019.

Molekul research summary: https://molekul.io/research/lineage-31393444. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Retinalamin

A retinal tissue-derived peptide preparation studied in ophthalmology. It is distinct from the short-peptide catalogue entry Normophthal.

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