HIF-1α and TSPO expression in heat-tolerant and heat-sensitive rats
A. E. Kim, E. B. Shustov, V. A. Kashuro, V. P. Ganapolsky, E. B. Katkova · 2023 · Pediatr. 14(3):31–41
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Reported findings and study design
Reported TSPO expression rose approximately 1.6–2-fold with severe heat exposure. HIF-1α expression varied by initial heat tolerance and condition. No peptide intervention was tested.
40 outbred rats screened for heat tolerance; four groups from higher- and lower-tolerance animals with or without heat exposure
Dose, route and schedule
20 minutes of air exposure at 40°C for heat-tolerance screening; qPCR on blood and tissue samples. No peptide dose.
Protocol source ↗ · Publisher PDF, heat-resistance grouping and qPCR results reviewed
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| TSPO expression | About 1.6–2-fold higher after extreme heat | Across measured tissues per authors, including both high- and low-tolerance groups. |
| HIF-1α expression | Reported differences around 1.5–2-fold in thermocomfort; 1.6–2.3-fold under heat | By tissue and resistance condition; not a drug-induced effect. |
A stress-physiology marker study, separate from the dissertation’s five-peptide comparison and DMAE derivative experiment.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Resistance groups were selected on heat response. The study does not validate prospective prediction in independent animals or workers.
- Expression correlations do not establish causal protection or increased ATP production.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publisher PDF, heat-resistance grouping and qPCR results reviewed
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Publisher PDF, heat-resistance grouping and qPCR results reviewed
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal article
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DOI: 10.17816/PED14331-41
Citation and original source
Original source: A. E. Kim, E. B. Shustov, V. A. Kashuro, V. P. Ganapolsky, E. B. Katkova. HIF-1α and TSPO expression in heat-tolerant and heat-sensitive rats Pediatr. 14(3):31–41 2023.
Molekul research summary: https://molekul.io/research/kim-hif-tspo-heat-2023. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
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