HIF-1α expression and hypoxia tolerance in rats
A. E. Kim, E. B. Shustov, V. A. Kashuro, V. P. Ganapolsky, E. B. Katkova · 2023 · Pediatr. 14(1):61–71
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Reported findings and study design
Baseline TSPO expression differed between animals classified by hypoxia tolerance. The authors reported higher HIF-1α expression in brain and liver relative to the reference gene. No drug was tested.
Outbred rats, 180–220 g, classified by experimental hypoxia tolerance; brain, heart, liver, kidney and blood expression measures
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Baseline TSPO by resistance group | 40–60% differences in kidney, liver and brain; 25% in heart | Reported comparison of high- and low-resistance animals in normoxia. |
| TSPO after hypoxic exposure | About 1.6–2-fold higher | Reported across tissues and resistance groups. |
| HIF-1α relative expression | Brain >300-fold; liver >15-fold relative to reference-gene expression | Author-reported qPCR normalization, not fold changes caused by a treatment. |
A mechanistic context paper. Do not use the expression ratios as evidence that Pineamin or any other peptide changes HIF-1α or TSPO.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Classification by observed hypoxia response is not independent prospective validation.
- Relative qPCR expression and reference-gene ratios are not treatment-induced changes or direct ATP measurements.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original journal PDF; exposure groups and expression results checked
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Original journal PDF; exposure groups and expression results checked
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal article
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DOI: 10.17816/PED14161-71
Citation and original source
Original source: A. E. Kim, E. B. Shustov, V. A. Kashuro, V. P. Ganapolsky, E. B. Katkova. HIF-1α expression and hypoxia tolerance in rats Pediatr. 14(1):61–71 2023.
Molekul research summary: https://molekul.io/research/kim-hif-hypoxia-2023. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry