HAEEPGP against amyloid-β-induced neuropathology
Kechko OI, Mukhina KA, Yanvarev DV, Eremina SY, Katkova-Zhukotskaya OA, Chaprov KD, Drutskaya MS, Kozin SA, Makarov AA, Mitkevich VA · 2025 · Molecular Neurobiology, online 2025, issue 2026
Reported findings and study design
Iodine-125 radiotracer measurements, isothermal titration calorimetry, western blotting, ELISA and flow cytometry.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Radiolabeled mouse plasma half-life | Approximately 2× that of radiolabeled HAEE. | |
| Brain exposure | Higher radiolabeled HAEEPGP accumulation in 5xFAD mice than in wild-type mice. | |
| Glia and synaptic markers | The authors reported reduced glial activation and less synaptic degeneration. |
The journal abstract omits detailed group estimates. The conference abstract is a companion report from the same research program.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The journal abstract omits detailed group estimates. The conference abstract is a companion report from the same research program.
Related publications may cover the same research program or participants.
Source access
Original abstract checked for selected methods and findings.
Source reviewed 2026-11-12.
Source type: Journal publication
Citation and original source
Original source: Kechko OI, Mukhina KA, Yanvarev DV, Eremina SY, Katkova-Zhukotskaya OA, Chaprov KD, Drutskaya MS, Kozin SA, Makarov AA, Mitkevich VA. HAEEPGP against amyloid-β-induced neuropathology Molecular Neurobiology, online 2025, issue 2026 2025.
Molekul research summary: https://molekul.io/research/haeepgp-preclinical-2025. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry