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COMPOUND RECORD / HAEEPGP

HAEEPGPПептид HAEEPGP

Cognition
Source linked

What the studies found

Animal research · conference abstract · 2025

HAEEPGP mouse pharmacokinetics and amyloid binding

Mouse plasma half-life
56 ± 12 minutes for HAEEPGP versus 17 minutes for HAEE in the conference report.
Amyloid-β binding affinity
Kd 1.64 μM, with stronger binding reported for isomerized amyloid-β.

56 ± 12 minutes for HAEEPGP versus 17 minutes for HAEE in the conference report.

Study notes · methods, sources and limitations

Participants or model 5xFAD and wild-type mice, HMC3 microglial cells and transgenic nematodes

Design The abstract reports intravenous radiotracer experiments in mice, amyloid binding by calorimetry and experiments in cells and nematodes.

Important limitations

  • The numerical estimates come from the conference abstract. The companion journal abstract describes its radiolabeled half-life comparison as approximately twofold. Human pharmacokinetics remain uncharacterized.

Alzheimer’s & Dementia, conference supplement · Conference abstract

Original source or citation ↗

Study results and tables ↗

Animal research · 2025

HAEEPGP against amyloid-β-induced neuropathology

Radiolabeled mouse plasma half-life
Approximately 2× that of radiolabeled HAEE.
Brain exposure
Higher radiolabeled HAEEPGP accumulation in 5xFAD mice than in wild-type mice.
Glia and synaptic markers
The authors reported reduced glial activation and less synaptic degeneration.

Approximately 2× that of radiolabeled HAEE.

Study notes · methods, sources and limitations

Participants or model 5xFAD and wild-type mice, transgenic nematodes and cellular assays

Design Iodine-125 radiotracer measurements, isothermal titration calorimetry, western blotting, ELISA and flow cytometry.

Important limitations

  • The journal abstract omits detailed group estimates. The conference abstract is a companion report from the same research program.

Molecular Neurobiology, online 2025, issue 2026 · Journal publication

Original source or citation ↗

Study results and tables ↗
01 / OVERVIEW

About HAEEPGP

Names in this research collection

HAEE-PGP · His-Ala-Glu-Glu-Pro-Gly-Pro

HAEEPGP extends HAEE with Pro-Gly-Pro. Researchers have studied amyloid binding, mouse pharmacokinetics and neuropathology in experimental models.

Research background

HAEEPGP extends HAEE with Pro-Gly-Pro. Researchers have studied amyloid binding, mouse pharmacokinetics and neuropathology in experimental models.

Alzheimer’s research evidence map ↗

Related HAEE patent results ↗ · HAEE patent records ↗. These filings cover HAEE preparations. An exact-sequence HAEEPGP filing was not verified.

Compound class
Synthetic heptapeptide
Research collection
Neuropeptide research · editorial grouping
Research institutions
No institutional affiliation recorded
Source review
Review dates and the material assessed are listed with each publication below.
02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research

The linked reports cover experimental models.

Study methods

Radiotracer distribution, calorimetry, cell assays, 5xFAD mice and transgenic nematodes.

Independent replication

The journal article and conference abstract come from the same research program.

Source access

Journal and conference abstracts.

Safety evidence

Human pharmacokinetics and safety remain uncharacterized.

Open a topic for the evidence assessment.

More findings, background and history

What remains unclear

The available experimental studies leave human benefit and safety uncertain.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Several publications can describe the same participants.

Browse original study records ↗
03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2025 · HAEEPGP against amyloid-β-induced neuropathologyRadiolabeled mouse plasma half-life: Approximately 2× that of radiolabeled HAEE.
2025Animal / experimentalEnglish abstract

HAEEPGP against amyloid-β-induced neuropathology

· Journal publication

Kechko OI, Mukhina KA, Yanvarev DV, Eremina SY, Katkova-Zhukotskaya OA, Chaprov KD, Drutskaya MS, Kozin SA, Makarov AA, Mitkevich VA · Molecular Neurobiology, online 2025, issue 2026

Approximately 2× that of radiolabeled HAEE.

Results and tables

Reported findings and study design

Iodine-125 radiotracer measurements, isothermal titration calorimetry, western blotting, ELISA and flow cytometry.

Results · Original abstract.
MeasureResultComparison, timing and statistics
Radiolabeled mouse plasma half-lifeApproximately 2× that of radiolabeled HAEE.
Brain exposureHigher radiolabeled HAEEPGP accumulation in 5xFAD mice than in wild-type mice.
Glia and synaptic markersThe authors reported reduced glial activation and less synaptic degeneration.

The journal abstract omits detailed group estimates. The conference abstract is a companion report from the same research program.

Source for these results ↗ · Reviewed 2026-11-12

Population / setting
5xFAD and wild-type mice, transgenic nematodes and cellular assays
Source reviewed
Original abstract checked for selected methods and findings.
Study limitations
  • The journal abstract omits detailed group estimates. The conference abstract is a companion report from the same research program.

Reviewed 2026-11-12.

Read the source ↗
2025 · HAEEPGP mouse pharmacokinetics and amyloid bindingMouse plasma half-life: 56 ± 12 minutes for HAEEPGP versus 17 minutes for HAEE in the conference report.
2025Animal / experimentalEnglish abstract

HAEEPGP mouse pharmacokinetics and amyloid binding

· Conference abstract

Kechko O, Yanvarev D, Chaprov K, Mukhina K, Makarov A, Mitkevich V · Alzheimer’s & Dementia, conference supplement

56 ± 12 minutes for HAEEPGP versus 17 minutes for HAEE in the conference report.

Results and tables

Reported findings and study design

The abstract reports intravenous radiotracer experiments in mice, amyloid binding by calorimetry and experiments in cells and nematodes.

Results · Original abstract.
MeasureResultComparison, timing and statistics
Mouse plasma half-life56 ± 12 minutes for HAEEPGP versus 17 minutes for HAEE in the conference report.
Amyloid-β binding affinityKd 1.64 μM, with stronger binding reported for isomerized amyloid-β.

The numerical estimates come from the conference abstract. The companion journal abstract describes its radiolabeled half-life comparison as approximately twofold. Human pharmacokinetics remain uncharacterized.

Source for these results ↗ · Reviewed 2026-11-12

Population / setting
5xFAD and wild-type mice, HMC3 microglial cells and transgenic nematodes
Source reviewed
Original abstract checked for selected methods and findings.
Study limitations
  • The numerical estimates come from the conference abstract. The companion journal abstract describes its radiolabeled half-life comparison as approximately twofold. Human pharmacokinetics remain uncharacterized.

Reviewed 2026-11-12.

Read the source ↗

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗