HAEEPGP mouse pharmacokinetics and amyloid binding
Kechko O, Yanvarev D, Chaprov K, Mukhina K, Makarov A, Mitkevich V · 2025 · Alzheimer’s & Dementia, conference supplement
Reported findings and study design
The abstract reports intravenous radiotracer experiments in mice, amyloid binding by calorimetry and experiments in cells and nematodes.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Mouse plasma half-life | 56 ± 12 minutes for HAEEPGP versus 17 minutes for HAEE in the conference report. | |
| Amyloid-β binding affinity | Kd 1.64 μM, with stronger binding reported for isomerized amyloid-β. |
The numerical estimates come from the conference abstract. The companion journal abstract describes its radiolabeled half-life comparison as approximately twofold. Human pharmacokinetics remain uncharacterized.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The numerical estimates come from the conference abstract. The companion journal abstract describes its radiolabeled half-life comparison as approximately twofold. Human pharmacokinetics remain uncharacterized.
Related publications may cover the same research program or participants.
Source access
Original abstract checked for selected methods and findings.
Source reviewed 2026-11-12.
Source type: Conference abstract
Citation and original source
Original source: Kechko O, Yanvarev D, Chaprov K, Mukhina K, Makarov A, Mitkevich V. HAEEPGP mouse pharmacokinetics and amyloid binding Alzheimer’s & Dementia, conference supplement 2025.
Molekul research summary: https://molekul.io/research/haeepgp-aaic-2025. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry