Anxiolytic Effects of Gly-His-Lys Peptide and Its Analogs
I. I. Bobyntsev, O. I. Chernysheva, M. E. Dolgintsev, M. Yu. Smakhtin, A. E. Belykh · 2015 · Bulletin of Experimental Biology and Medicine 2015 158 726-728
Study data at a glance
- Participants or experimental model
- Male rats; elevated plus maze.
- Reported results
- Replacing L-lysine with D-lysine weakened the GHK behavioral signal. Adding D-alanine at either end removed the anxiolytic action; some measures indicated increased anxiety at the highest tested exposure.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal findings do not establish human efficacy, a human dose, or long-term safety.
- Improved wound-related findings for a D-alanine analogue cannot be generalized to improved neurobehavioral activity.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed primary abstract and publisher citation checked; full text not appraised.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Citation and original source
Original source: I. I. Bobyntsev, O. I. Chernysheva, M. E. Dolgintsev, M. Yu. Smakhtin, A. E. Belykh. Anxiolytic Effects of Gly-His-Lys Peptide and Its Analogs Bulletin of Experimental Biology and Medicine 2015 158 726-728 2015.
Molekul research summary: https://molekul.io/research/ghk-stereochemistry-anxiety-2015. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry