Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing
V. I. B. Castro, A. R. Araújo, R. L. Reis, I. Pashkuleva, R. A. Pires · 2025 · ACS Applied Materials & Interfaces. 2025;17(8):11624–11633.
Published 2025-02-12.
Study data at a glance
- Participants or experimental model
- Self-assembly, proteolysis and laboratory wound-healing assays.
- Reported results
- Covalently linked constructs formed more proteolytically stable assemblies than the coassembled system. The experimental structures improved healing-related activity compared with GHK alone.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal findings do not establish human efficacy, a human dose, or long-term safety.
- Stability and cell-assay findings do not demonstrate a longer human half-life or improved clinical wound healing.
- F4D-KHG uses an inverted sequence; these constructs are not ordinary GHK-Cu.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Original open-access article, abstract, construct identities and main conclusions checked; formal bias assessment pending.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Citation and original source
Original source: V. I. B. Castro, A. R. Araújo, R. L. Reis, I. Pashkuleva, R. A. Pires. Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing ACS Applied Materials & Interfaces. 2025;17(8):11624–11633. 2025.
Molekul research summary: https://molekul.io/research/ghk-self-assembly-2025. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry