Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide
G.-H. Hur, S.-C. Han, A.-R. Ryu, Y. Eom, J.-W. Kim, M.-Y. Lee · 2020 · Journal of Peptide Science. 2020;26:e3234. Online 1 December 2019.
Published 2019-12-01.
Study data at a glance
- Participants or experimental model
- Cell assays and experimental skin-delivery comparisons; not a controlled human wrinkle trial.
- Reported results
- Adding four C-terminal arginines increased uptake and experimental delivery, with greater collagen-related activity and MMP inhibition than unmodified GHK in the tested systems.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal findings do not establish human efficacy, a human dose, or long-term safety.
- Enhanced delivery and cellular collagen measurements do not establish a clinical antiwrinkle effect.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Original publisher abstract checked; full methods and delivery model details require review.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.1002/psc.3234
Citation and original source
Original source: G.-H. Hur, S.-C. Han, A.-R. Ryu, Y. Eom, J.-W. Kim, M.-Y. Lee. Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide Journal of Peptide Science. 2020;26:e3234. Online 1 December 2019. 2020.
Molekul research summary: https://molekul.io/research/ghk-r4-delivery-2020. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry