Anxiolytic Effects of GHK-GP Peptide and its Structural Analogues in Elevated Plus Maze Test
M. E. Alferova, I. I. Bobyntsev, A. O. Vorvul, A. N. Tenkova, L. A. Andreeva, N. F. Myasoedov · 2025 · Journal Biomed 2025 21 49-57
Published 2025-06-10.
Study data at a glance
- Participants or experimental model
- 200 male Wistar rats; elevated plus maze.
- Reported results
- GHK-GP produced an anxiolytic-like signal at two tested exposures, while GHK-VEP did not. Adding a proline-containing ending changed the behavioral profile rather than producing a uniform class effect.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal findings do not establish human efficacy, a human dose, or long-term safety.
- Acute behavioral proxy with multiple peptides and exposures; durability and proteolytic stability were not established by these behavioral results.
- The PDF gives 10 June 2025; Crossref gives 4 July 2025. These describe one publication, not two studies.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed original Russian PDF abstract and selected result passages checked against the publisher-deposited Crossref abstract; complete statistical appraisal pending.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Citation and original source
Original source: M. E. Alferova, I. I. Bobyntsev, A. O. Vorvul, A. N. Tenkova, L. A. Andreeva, N. F. Myasoedov. Anxiolytic Effects of GHK-GP Peptide and its Structural Analogues in Elevated Plus Maze Test Journal Biomed 2025 21 49-57 2025.
Molekul research summary: https://molekul.io/research/ghk-proline-maze-2025. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry