A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK
J. D. Campbell, J. E. McDonough, J. E. Zeskind, T. L. Hackett, D. V. Pechkovsky, and colleagues · 2012 · Genome Medicine. 2012;4:67.
Study data at a glance
- Participants or experimental model
- 64 lung-tissue samples from 8 COPD lungs for discovery, followed by cell-culture experiments; patients were not treated with GHK.
- Reported results
- GHK reversed parts of an emphysema-associated expression signature and restored collagen contraction/remodeling in cultured COPD-derived fibroblasts.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Human-derived tissue is not a human treatment trial.
- Gene-expression changes do not establish reversal of emphysema, clinical rejuvenation or increased human lifespan.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Primary indexed or publisher abstract and citation checked; complete methods, tables and risk of bias not appraised.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.1186/gm367
Citation and original source
Original source: J. D. Campbell, J. E. McDonough, J. E. Zeskind, T. L. Hackett, D. V. Pechkovsky, and colleagues. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK Genome Medicine. 2012;4:67. 2012.
Molekul research summary: https://molekul.io/research/ghk-lung-signature-2012. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry