Regenerative effects of Gly-His-Lys and Gly-His-Lys-D-Ala peptides in infected skin wounds
KK Rakhmetova, ES Mishina, AO Vorvul, II Bobyntsev, ME Dolgintsev, AI Bezhin · 2022 · Bulletin of RSMU. 2022;(2):58–64 (English version).
Published 2022-04-13.
Study data at a glance
- Participants or experimental model
- 150 male rats; wound histomorphometry at days 3, 7 and 10.
- Reported results
- GHK-D-Ala shifted wound-cell composition toward repair and away from inflammation. The lower tested exposure showed the strongest histological signal; increasing exposure did not improve the effect.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal findings do not establish human efficacy, a human dose, or long-term safety.
- Histological markers are distinct from complete clinical healing; the same group’s related publications are not independent replication.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Original publisher English text, abstract and histological conclusions checked; formal risk-of-bias assessment pending.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Citation and original source
Original source: KK Rakhmetova, ES Mishina, AO Vorvul, II Bobyntsev, ME Dolgintsev, AI Bezhin. Regenerative effects of Gly-His-Lys and Gly-His-Lys-D-Ala peptides in infected skin wounds Bulletin of RSMU. 2022;(2):58–64 (English version). 2022.
Molekul research summary: https://molekul.io/research/ghk-dala-regeneration-2022. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry