Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-L-histidyl-L-lysine copper
G. D. Mulder, L. M. Patt, L. Sanders, J. Rosenstock, M. I. Altman, M. E. Hanley, G. W. Duncan · 1994 · Wound Repair and Regeneration. 1994;2(4):259–269.
Reported findings and study design
Multicenter randomized evaluator-blinded vehicle-controlled diabetic neuropathic-ulcer study; enrollment denominator not verified from the checked abstract.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Median plantar-ulcer area closure | 98.5% with GHK-Cu gel | 60.8% with vehicle · p<0.05 |
| Larger plantar-ulcer subgroup | 89.2% median area closure | −10.3% with vehicle · p<0.01 |
Disease-specific topical formulation alongside intensive wound care; not evidence for injectable GHK-Cu or healthy-person recovery. Full cohort accounting, subgroup prespecification and complete adverse-event tables require the original paper.
Source for the extracted data ↗ · Checked 2026-11-03
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Disease-specific topical formulation alongside intensive wound care; not evidence for injectable GHK-Cu or healthy-person recovery.
- Full cohort accounting, subgroup prespecification and complete adverse-event tables require the original paper.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Primary indexed or publisher abstract and citation checked; complete methods, tables and risk of bias not appraised.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Citation and original source
Original source: G. D. Mulder, L. M. Patt, L. Sanders, J. Rosenstock, M. I. Altman, M. E. Hanley, G. W. Duncan. Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-L-histidyl-L-lysine copper Wound Repair and Regeneration. 1994;2(4):259–269. 1994.
Molekul research summary: https://molekul.io/research/ghk-cu-diabetic-ulcers-1994. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry