Effects of opioid peptide dalargin on reparative processes in wound healing
Shekhter AB, Solov'eva AI, Spevak SE, Titov MI · 1988 · Biull Eksp Biol Med. 1988;106(10):487-490. PMID 3191245
This source appears in the Thymalin–Dalargin evidence review. A single-agent experiment, comparative study or patent alternative is not automatically a combined-treatment trial.
Reported findings and study design
Reported findings
The abstract reports a threefold fibroblast mitotic-index increase, capillary growth and faster maturation/epithelialization in rat wounds. It does not give a numerical reduction in healing days.
Rat skin wounds; group sizes and observation times absent from the checked abstract.
Dose, route and schedule
Intraperitoneal injection and local Dalargin application; dose, frequency and observation duration unavailable in the checked abstract.
Protocol source ↗ · Original indexed abstract; historical research methods
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Fibroblast proliferation | 3-fold increase in mitotic index reported | Rat wound tissue; raw indices, uncertainty and route-specific contrasts unavailable |
| Repair outcomes | Capillary growth, granulation/scar maturation and epithelialization described as faster | No verified numerical days-to-closure estimate; threefold mitosis is not threefold faster healing |
| Reported routes | Intraperitoneal injection and local application | Dose, frequency and duration not supplied by the checked abstract |
| Safety | No adverse-event counts or long-term scarring outcomes supplied |
Findings apply to this preparation, assay and comparison. They do not establish Thymalin–Dalargin combination efficacy or a safe combined regimen.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- No dose, denominator, exact observation schedule or numerical healing-time table in the checked abstract.
- Separate single-agent animal research; it does not establish Thymalin–Dalargin synergy or human wound benefits.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original indexed abstract
Review depth: Indexed abstract and citation checked; full original outcome tables not recovered
Source access and review scope
Original PubMed / Europe PMC indexed abstract checked. Missing group sizes, doses, raw outcomes and uncertainty are not reconstructed.
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Shekhter AB, Solov'eva AI, Spevak SE, Titov MI. Effects of opioid peptide dalargin on reparative processes in wound healing Biull Eksp Biol Med. 1988;106(10):487-490. PMID 3191245 1988.
Molekul research summary: https://molekul.io/research/dalargin-wound-repair-1988. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry