The effect of endogenous opioid peptides and their synthetic analogs on the activity of natural killer cells
Uteshev BS, Korostelev SA, Isakova KL, Shchegolev AI · 1994 · Eksp Klin Farmakol. 1994;57(1):55-57. PMID 8142867
This source appears in the Thymalin–Dalargin evidence review. A single-agent experiment, comparative study or patent alternative is not automatically a combined-treatment trial.
Reported findings and study design
Narrative findings; numerical extraction incomplete
Dalargin and endogenous opioid peptides enhanced NK-cell cytolytic activity in the abstract; no numerical effect size was supplied.
Natural-killer-cell culture assays; the indexed record includes mouse/animal terms, not a human treatment cohort. Sample counts unavailable.
Protocol information
Dose, route and treatment schedule are not sufficiently described in the checked abstract.
Protocol source ↗ · Original indexed abstract; protocol unavailable
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| NK-cell cytolysis | Increase described with Dalargin and endogenous peptides | Cell-culture endpoint, not a clinical antitumor response |
| Numerical extraction gap | No concentration, effect magnitude, denominator or uncertainty in the checked abstract |
Findings apply to this preparation, assay and comparison. They do not establish Thymalin–Dalargin combination efficacy or a safe combined regimen.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Do not substitute the 1988 human-cell assay’s concentration for this separate study.
- No Thymalin combination, human treatment or cancer-survival benefit established.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original indexed abstract
Review depth: Indexed abstract and citation checked; full original outcome tables not recovered
Source access and review scope
Original PubMed / Europe PMC indexed abstract checked. Missing group sizes, doses, raw outcomes and uncertainty are not reconstructed.
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Uteshev BS, Korostelev SA, Isakova KL, Shchegolev AI. The effect of endogenous opioid peptides and their synthetic analogs on the activity of natural killer cells Eksp Klin Farmakol. 1994;57(1):55-57. PMID 8142867 1994.
Molekul research summary: https://molekul.io/research/dalargin-nk-cytotoxicity-1994. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry