Importance of opiate receptor ligands in regulating lymphocyte proliferative activity
Zozulia AA, Voronkova TL, Patsakova E, Ivanushkin AM · 1987 · Farmakol Toksikol. 1987;50(3):58-59. PMID 3038604
This source appears in the Thymalin–Dalargin evidence review. A single-agent experiment, comparative study or patent alternative is not automatically a combined-treatment trial.
Reported findings and study design
Narrative findings; numerical extraction incomplete
Dalargin inhibited phytohemagglutinin-driven lymphocyte proliferation at 10⁻¹²–10⁻⁷ M; naloxone blocked that effect.
Cultured human peripheral-blood lymphocytes stimulated with polyclonal mitogens; donor and replicate counts unavailable.
Dose, route and schedule
Dalargin 10⁻¹²–10⁻⁷ M in stimulated human lymphocyte cultures; the abstract lists naloxone 10⁻⁸–10⁻⁶ M. Exposure duration unavailable.
Protocol source ↗ · Original indexed abstract; historical research methods
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Mitogen-induced proliferation | Inhibited by Dalargin at 10⁻¹²–10⁻⁷ M | Human-cell assay; no numerical inhibition percentage or donor count supplied |
| Naloxone contrast | Blocked the reported Dalargin-associated inhibition | Assay-specific pharmacology, not proof of a beneficial immune effect in people |
| Experimental concentration | Dalargin 10⁻¹²–10⁻⁷ M; naloxone range 10⁻⁸–10⁻⁶ M | Culture concentrations, not human doses; timing unavailable |
Findings apply to this preparation, assay and comparison. They do not establish Thymalin–Dalargin combination efficacy or a safe combined regimen.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- No donor count, numerical response curve or effect uncertainty in the abstract.
- Opioid ligands and mitogen conditions differ; no Thymalin combination or human immune outcome was tested.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original indexed abstract
Review depth: Indexed abstract and citation checked; full original outcome tables not recovered
Source access and review scope
Original PubMed / Europe PMC indexed abstract checked. Missing group sizes, doses, raw outcomes and uncertainty are not reconstructed.
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Zozulia AA, Voronkova TL, Patsakova E, Ivanushkin AM. Importance of opiate receptor ligands in regulating lymphocyte proliferative activity Farmakol Toksikol. 1987;50(3):58-59. PMID 3038604 1987.
Molekul research summary: https://molekul.io/research/dalargin-lymphocyte-inhibition-1987. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry