On the character of Dalargin’s influence on duodenal secretory epithelial cells
V. L. Mogilnaya · 2007 · Uspekhi sovremennogo estestvoznaniia. 2007;(12, part 1):33–36.
This source appears in the Thymalin–Dalargin evidence review. A single-agent experiment, comparative study or patent alternative is not automatically a combined-treatment trial.
Reported findings and study design
Reported findings
The paper reports phase- and tissue-dependent mucin changes: a villus mucin-production index rose from a reported baseline 60.56±4.01 to 110.2±0.75 by day 3; early crypt and trefoil responses were mixed.
Male Wistar rats, intact mucosa and experimental duodenal-ulcer conditions; three described groups, but animal counts not reported.
Dose, route and schedule
Dalargin 24 µg/kg every 12 hours in the intact-animal parenteral group; the ulcer group received subcutaneous Dalargin every 12 hours without restating its dose. Intact-group assessments days 1, 2, 4 and 7; ulcer-group days 1–3. No missing ulcer-group dose is silently filled in.
Protocol source ↗ · Original methods, p.33; route and dose statements kept source-specific
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Villus mucin-production index | Reported baseline 60.56±4.01; 110.2±0.75 at day 3 with Dalargin | Histochemical index, source-specific units; not an 82% clinical healing benefit. Original uncertainty type not defined. |
| Separate untreated-ulcer reference | 57.7±0.95 reported for villus mucin production without Dalargin | Conclusion gives this reference separately; no matched-time treatment effect or confidence interval inferred |
| Crypt mucin response in ulcer conditions | No response to Dalargin over the first three days described | Neutral location-specific finding, despite the favorable villus narrative |
| Intact-mucosa early crypt coefficient | 2.19±0.07 in controls versus 1.85±0.1 after Dalargin | Neutral-mucin cytochemical coefficient; an early decrease, not uniform stimulation · Day 1 · p<0.01 |
| Trefoil-peptide signal | Early fall after Dalargin in ulcer-bearing animals, followed by return toward initial levels on days 2–3 | Qualitative histochemistry; no clinical consequence established |
This paper extends the mucosal-repair hypothesis while showing phase- and compartment-dependent responses. It is not a Thymalin combination experiment or a quantified clinical healing trial.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- No animal group sizes, masking or complete statistical plan supplied.
- Histochemical indices are surrogate tissue measures, not clinical ulcer-healing percentages.
- The source gives both a general baseline and an untreated-ulcer reference; they are not interchangeable control time points.
- Intact and ulcer-bearing animals show different time courses. Dose is explicitly printed for the intact group but not repeated for the ulcer group.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original publisher PDF indexed full text; original page images not visually inspected
Review depth: Methods and selected numerical narrative outcomes checked in the original indexed four-page paper
Source access and review scope
Original publisher indexed PDF pp.33–36, including the untreated-ulcer value and neutral/early-decrease passages. Sample sizes and the type of ± uncertainty are not established. Original PDF page images unavailable.
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original animal journal publication
Citation and original source
Original source: V. L. Mogilnaya. On the character of Dalargin’s influence on duodenal secretory epithelial cells Uspekhi sovremennogo estestvoznaniia. 2007;(12, part 1):33–36. 2007.
Molekul research summary: https://molekul.io/research/dalargin-duodenal-mucins-2007. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry