Blood flow in skin wound tissue and systemic hemodynamics as affected by a collagen-dalargin complex
Medvedev OS, Khulup GIa, Spevak SE, Istranov LP, Titov MI · 1987 · Biull Eksp Biol Med. 1987;104(12):651-654. PMID 2446676
This source appears in the Thymalin–Dalargin evidence review. A single-agent experiment, comparative study or patent alternative is not automatically a combined-treatment trial.
Reported findings and study design
Narrative findings; numerical extraction incomplete
A collagen–Dalargin preparation increased wound-granulation blood flow and capillary formation, while capillary blood flow in unaffected tissue was unchanged.
Rat skin-wound/granulation-tissue experiment; sample sizes unavailable in the indexed abstract.
Protocol information
Dose, route and treatment schedule are not sufficiently described in the checked abstract.
Protocol source ↗ · Original indexed abstract; protocol unavailable
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Wound microcirculation | Increased granulation-tissue blood flow, new capillary formation and lower vascular resistance described | Microsphere method; no numerical flow values or effect uncertainty in the abstract |
| Unaffected tissue | No effect on capillary blood flow reported | Neutral tissue-specific finding |
| Preparation boundary | The tested preparation was a collagen–Dalargin complex | No Thymalin co-treatment or general formulation equivalence established |
Findings apply to this preparation, assay and comparison. They do not establish Thymalin–Dalargin combination efficacy or a safe combined regimen.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Original carrier controls, dose, route, sample sizes and numerical hemodynamic tables require full text.
- A local wound-flow finding is not a general increase in systemic circulation or proof of clinical healing.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original indexed abstract
Review depth: Indexed abstract and citation checked; full original outcome tables not recovered
Source access and review scope
Original PubMed / Europe PMC indexed abstract checked. Missing group sizes, doses, raw outcomes and uncertainty are not reconstructed.
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Medvedev OS, Khulup GIa, Spevak SE, Istranov LP, Titov MI. Blood flow in skin wound tissue and systemic hemodynamics as affected by a collagen-dalargin complex Biull Eksp Biol Med. 1987;104(12):651-654. PMID 2446676 1987.
Molekul research summary: https://molekul.io/research/dalargin-collagen-wound-flow-1987. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry