Neuropeptide Cyclo-Prolylglycine: Discovery, Pharmacological Effects, and Mechanism of Action
T. A. Gudasheva, K. N. Koliasnikova, A. G. Alyaeva, P. Yu. Povarnina · 2025 · Neurochemical Journal 19:549–556 (2025); published online 13 January 2026
Study data at a glance
- Participants or experimental model
- Narrative synthesis of CPG research
- Reported results
- The authors discuss two proposed mechanisms: IGF-1 homeostasis and AMPA modulation with downstream neurotrophin signaling. The review connects the endogenous peptide with the Noopept research lineage.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- A synthesis of earlier studies, not a new efficacy trial or independent replication.
- Publisher abstract and references checked; subscription full text not reviewed.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Publisher abstract and bibliography
Source access and review scope
Primary publisher abstract, publication dates and references checked.
Recorded source-check date: 2026-10-17. This date does not imply a completed systematic review.
Citation and original source
Original source: T. A. Gudasheva, K. N. Koliasnikova, A. G. Alyaeva, P. Yu. Povarnina. Neuropeptide Cyclo-Prolylglycine: Discovery, Pharmacological Effects, and Mechanism of Action Neurochemical Journal 19:549–556 (2025); published online 13 January 2026 2025.
Molekul research summary: https://molekul.io/research/cpg-review-2025. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
CPG & GZK-111
A grouped record for endogenous cyclo(Pro-Gly), its experimental linear precursor GZK-111 and the connection to Noopept metabolism.
Noopept
A defined synthetic dipeptide derivative connecting nootropic research with experimental environmental adaptation. Human chamber studies, clinical EEG reports and preclinical mechanisms address different questions; none establishes safe hazardous-work use.