Bromantane and splenic T-cell populations after 20 days of social stress in mice
A. V. Tallerova, L. P. Kovalenko, A. D. Durnev, S. B. Seredenin · 2012 · Russian Journal of Biotherapy. 2012;11(1):39–43.
Reported findings and study design
Reported findings
Male C57BL/6 mice underwent 20 days of social stress. Stressed groups received saline or Bromantane 30 mg/kg intraperitoneally on days 16–20 (10 per arm). An unstressed group served as a reference. Researchers measured organ weight and splenic T-cell percentages by flow cytometry one day after the final dose.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Splenic CD3+ T cells | 31.3% vs 27.9% | Bromantane vs saline; unstressed 32.0% |
| Splenic CD4+CD8− cells | 19.3% vs 17.1% | Bromantane vs saline; unstressed 21.8% |
| Thymus mass index | 14.4 vs 14.8 mg per 10 g body mass | Bromantane vs saline; unstressed 22.2 mg per 10 g |
Splenic T-cell subsets (Table 5)
| Percent of cells | Unstressed | Stress + saline | Stress + Bromantane |
|---|---|---|---|
| CD3+ | 32.0 ± 0.8 | 27.9 ± 1.3 | 31.3 ± 1.0 |
| CD4+CD8− | 21.8 ± 1.0 | 17.1 ± 1.1 | 19.3 ± 0.9 |
| CD4−CD8+ | 10.7 ± 0.7 | 9.4 ± 0.5 | 11.0 ± 0.5 |
The authors report p<0.05 for saline versus unstressed controls on CD3+ and CD4+CD8−. The table gives no direct drug-versus-saline p values.
Cell proportions moved toward the unstressed values. The authors found no effect on the stress-associated change in lymphoid organ mass.
Source for these results ↗ · Reviewed 2026-11-10
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The T-cell table marks tests against unstressed controls and does not report a direct Bromantane–saline p value.
- The related 2014 publication describes a 30-day model. Whether these reports shared animals is unresolved.
Related publications may cover the same research program or participants.
Source access
Original journal issue, Methods and Tables 2–5 checked.
Source reviewed 2026-11-10.
Citation and original source
Original source: A. V. Tallerova, L. P. Kovalenko, A. D. Durnev, S. B. Seredenin. Bromantane and splenic T-cell populations after 20 days of social stress in mice Russian Journal of Biotherapy. 2012;11(1):39–43. 2012.
Molekul research summary: https://molekul.io/research/bromantane-tallerova-social-stress-2012. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry