RESEARCH ATLAS
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COMPOUND RECORD / VIR-8

VIR-8ВИР-8

PerformanceStressRecovery
Source linked
01 / OVERVIEW

About VIR-8

Names in this research collection

VIR 8 · ВИР 8 · Mobitek-M polypeptide complex

A named Mobitek-M polypeptide complex tested in mice during combined oxygen and temperature stress. The article supplies a route and dose but does not disclose sequences, molecular-weight fractions or an identity match to PPK-V.

Research background

A named Mobitek-M polypeptide complex tested in mice during combined oxygen and temperature stress. The article supplies a route and dose but does not disclose sequences, molecular-weight fractions or an identity match to PPK-V.

What the studies found

Animal research · 2021

Who or what was studiedMale outbred mice, 18–21 g; 10 randomized per group; loaded swim at 5% body mass after sodium nitrite-induced hemic hypoxia

Reported finding

VIR-8 extended swimming under hypoxia plus cold (12.5±1.3 vs 4.5±0.4 seconds) but did not improve swimming under hypoxia plus heat (16.8±1.5 vs 16.9±2.3 seconds).

VIR-8 · hypoxia plus cold
12.5±1.3 versus 4.5±0.4 s; +178%p=0.0002Table 3; compared with stressed control, n=10 per group
VIR-8 · hypoxia plus heat
16.8±1.5 versus 16.9±2.3 s; 0% reportedp=0.99Table 1; compared with stressed control
VIR-8 · hypoxia at normal temperature
29.8±4.2 versus 24.4±2.7 sSame thermoneutral series is displayed in Tables 1 and 3. Do not count it twice.
All reported results & study design →
Methods, dose & source notes

Study of multiple preparations · Original journal article

Each comparator used its own formulation, dose and schedule. The short mouse swim endpoint cannot establish human cold tolerance, prevention of heat injury or improved sports performance. The paper does not identify VIR-8 sequences or establish an identity match with PPK-V.

VIR-8, Hypoxen and comparators under hypoxia with heat or cold ↗

These highlights cover selected studies. Open a source for its methods, reported doses and full context.

Compound class
Experimental polypeptide complex
Research collection
Actoprotection & occupational pharmacology · editorial grouping
Research institutions
No institutional affiliation recorded
Source review
Review dates and the material assessed are listed with each publication below.
02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research

No human intervention recovered.

Study methods

Mouse loaded-swim comparison, n=10 per group; the positive cold result and neutral heat result are reported together.

Independent replication

Independent replication is not established in the linked sources.

Source access

Original sources and the exact review scope are linked below.

Safety evidence

The linked experiments do not establish a safe human performance regimen.

Open a topic for the evidence assessment.

More findings, background and history
EVIDENCE REVIEW / 6 OCTOBER 2026

Outstanding review questions

Appraise original methods and replication; keep animal and cell findings separate from unestablished human benefit and safety.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Publication records can share participants. Source counts are not trial counts.

Browse original study records ↗
03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2021 · VIR-8, Hypoxen and comparators under hypoxia with heat or coldVIR-8 · hypoxia plus cold: 12.5±1.3 versus 4.5±0.4 s; +178%
2021Animal / experimentalFull text available

VIR-8, Hypoxen and comparators under hypoxia with heat or cold

VIR-8 is a separately named polypeptide complex from Mobitek-M. Hypoxen, trimetazidine and food preparations were distinct arms. · Original journal article

Format: Original publisher issue PDF, printed pp. 57–69; methods and Tables 1 and 3 checked · Reviewed: Reported methods, results and evidence limitations

E. B. Shustov, Yu. V. Fokin, S. L. Lyublinskiy, O. V. Alimkina, A. E. Kim, D. Yu. Ivkin, E. L. Matveenko, A. S. Ivkina, G. A. Plisko, M. A. Poveryaeva · Biomeditsina. 17(1):57–69

VIR-8 extended swimming under hypoxia plus cold (12.5±1.3 vs 4.5±0.4 seconds) but did not improve swimming under hypoxia plus heat (16.8±1.5 vs 16.9±2.3 seconds).

Findings, study figures and available tables

Reported findings and study design

VIR-8 extended swimming under hypoxia plus cold (12.5±1.3 vs 4.5±0.4 seconds) but did not improve swimming under hypoxia plus heat (16.8±1.5 vs 16.9±2.3 seconds).

Male outbred mice, 18–21 g; 10 randomized per group; loaded swim at 5% body mass after sodium nitrite-induced hemic hypoxia

Dose, route and schedule

VIR-8: 5 mg/kg rectally in 0.5 mL starch vehicle daily for 5 days. Hypoxen: 50 mg/kg orally by gavage once, 1 hour before testing. Sodium nitrite: 50 mg/kg intraperitoneally for hemic hypoxia. Main swim load: 5% body mass.

Protocol source ↗ · Original publisher issue PDF, printed pp. 57–69; methods and Tables 1 and 3 checked

Reported findings and study figures · Original publisher issue PDF, printed pp. 57–69; methods and Tables 1 and 3 checked
MeasureResultComparison, timing and statistics
VIR-8 · hypoxia plus cold12.5±1.3 versus 4.5±0.4 s; +178%Table 3; compared with stressed control, n=10 per group · p=0.0002
VIR-8 · hypoxia plus heat16.8±1.5 versus 16.9±2.3 s; 0% reportedTable 1; compared with stressed control · p=0.99
VIR-8 · hypoxia at normal temperature29.8±4.2 versus 24.4±2.7 sSame thermoneutral series is displayed in Tables 1 and 3. Do not count it twice.
Hypoxen · hypoxia plus cold10.0±0.9 versus 4.5±0.4 s; +120%Table 3; compared with stressed control · p=3×10⁻⁵
Hypoxen · hypoxia plus heat22.7±3.5 versus 16.9±2.3 s; +34%Table 1; nonsignificant versus stressed control · p=0.18
Other arms · directional reversalFlamenco 50 mg/kg: −37% in heat, +111% in coldDifferent comparator preparation; not a VIR-8 result. Low-dose heat comparison p=0.02; cold p=2×10⁻¹² as printed.
Safety and sequenceNo human safety study or sequence-level characterization reportedThe designation VIR-8 is insufficient to infer constituent peptides.
Tables 1 and 3 · forced swimming across stress conditions
Tables 1 and 3 · forced swimming across stress conditions
GroupHypoxia, normal temperature (s)Hypoxia + heat (s)Heat effect vs controlHypoxia + cold (s)Cold effect vs control
Intact comparator72.6±7.063.5±7.9—5.6±0.7—
Stressed control24.4±2.716.9±2.3Reference4.5±0.4Reference
MioActive Sport24.8±2.716.9±1.3+2%; p=0.9918.4±1.5+308%; p=2×10⁻¹¹
VIR-829.8±4.216.8±1.50%; p=0.9912.5±1.3+178%; p=0.0002
Flamenco 50 mg/kg19.3±1.510.6±0.9−37%; p=0.029.5±1.1+111%; p=2×10⁻¹²
Flamenco 75 mg/kg21.5±5.014.6±1.8−14%; p=0.4312.9±0.8+187%; p=2×10⁻¹⁰
Flamenco 250 mg/kg20.7±2.834.4±4.7+104%; p=0.0036.9±1.0+53%; p=2×10⁻¹²
Trimetazidine22.7±11.187.3±18.2+418%; p=0.016.7±0.3+49%; p=2×10⁻¹⁷
Hypoxen30.1±4.322.7±3.5+34%; p=0.1810.0±0.9+120%; p=3×10⁻⁵

M±m and reported p-values transcribed from the article. Percentages are the authors’ reported changes relative to stressed controls, not comparisons between active arms. The intact groups do not receive hemic hypoxia; the displayed first column represents the relevant normothermic baseline.

Retain the neutral heat result alongside the positive cold result. The model examines hemic hypoxia during temperature stress, not altitude acclimatization or actual outdoor work. The distinct products cannot be ranked as equivalent-dose interventions.

Source for the extracted data ↗ · Checked 2026-11-08

Population / setting
Male outbred mice, 18–21 g; 10 randomized per group; loaded swim at 5% body mass after sodium nitrite-induced hemic hypoxia
What was checked
Original publisher issue PDF, printed pp. 57–69; methods and Tables 1 and 3 checked
Limitations & review scope
  • Each comparator used its own formulation, dose and schedule.
  • The short mouse swim endpoint cannot establish human cold tolerance, prevention of heat injury or improved sports performance.
  • The paper does not identify VIR-8 sequences or establish an identity match with PPK-V.

Source checked 2026-11-08. See the review scope above for the material assessed.

Read the source ↗

Follow shared publications or research classes. These links do not establish equivalent effects between compounds.

Hypoxen / Olifen research ↗

1 shared source record

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

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