RESEARCH ATLAS
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COMPOUND RECORD / SUCCINIC-ACID

Succinic acidЯнтарная кислота

StressPerformance
Source linked

What the studies found

Animal research · 2016

Metaprot and succinic acid in acute hypoxia in mice

Study of multiple preparations

Combination vs control
18.8% longer survival timeReported p ≤ 0.05 vs control.
Metaprot vs control
16.1% longer survival timeReported p ≤ 0.05 vs control.
Succinic acid vs control
14.9% longer survival timeNo p value supplied.

Survival time under hypoxia was reported as 16.1% longer with Metaprot, 14.9% longer with succinic acid and 18.8% longer with both, each relative to control.

Study notes · methods, sources and limitations

Participants or model 40 outbred white mice in four groups of ten.

Design Four groups of 10 mice received control, Metaprot, succinic acid or their combination. Each active ingredient was given intragastrically at 50 mg/kg. The endpoint was survival time in the acute hypoxia model.

Important limitations

  • The abstract gives no absolute survival times, uncertainty intervals, direct combination-versus-monotherapy test or formal interaction test. Related proceedings versions should be treated as the same experiment.
  • The combination exceeded the Metaprot estimate by 2.7 percentage points. A difference between those arms and a synergistic interaction were not established.

Bulletin of Medical Internet Conferences. Vol. 5, no. 12, p. 1770. Posted 30 January 2016. · Conference abstract

Original source or citation ↗

Study results and tables ↗
01 / OVERVIEW

About Succinic acid

Names in this research collection

Succinate · Butanedioic acid

A metabolic substrate tested alone and with Metaprot in a small mouse hypoxia experiment. The study used succinic acid, distinct from Bemitil succinate or mixed succinate salts.

Research background

A metabolic substrate tested alone and with Metaprot in a small mouse hypoxia experiment. The study used succinic acid, distinct from Bemitil succinate or mixed succinate salts.

Compound class
Metabolic substrate
Research collection
Actoprotection & occupational pharmacology · editorial grouping
Research institutions
No institutional affiliation recorded
Source review
Review dates and the material assessed are listed with each publication below.
02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research

Mouse hypoxia experiment

Study methods

Four-group comparison with time-to-death endpoint

Independent replication

Independent replication not established for this comparison

Source access

Conference abstract

Safety evidence

Human combination safety not assessed

Open a topic for the evidence assessment.

More findings, background and history

What remains unclear

The available experimental studies leave human benefit and safety uncertain.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Several publications can describe the same participants.

Browse original study records ↗
03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2016 · Metaprot and succinic acid in acute hypoxia in miceCombination vs control: 18.8% longer survival time
2016Animal / experimentalRussian source · see review scope

Metaprot and succinic acid in acute hypoxia in mice

· Conference abstract

V. D. Dekkanova, V. R. Danilov, M. S. Polyakova · Bulletin of Medical Internet Conferences. Vol. 5, no. 12, p. 1770. Posted 30 January 2016.

Survival time under hypoxia was reported as 16.1% longer with Metaprot, 14.9% longer with succinic acid and 18.8% longer with both, each relative to control.

Results and tables

Reported findings and study design

Reported findings

Four groups of 10 mice received control, Metaprot, succinic acid or their combination. Each active ingredient was given intragastrically at 50 mg/kg. The endpoint was survival time in the acute hypoxia model.

Dose, route and schedule

Each active agent was administered intragastrically at 50 mg/kg. The combination used 50 mg/kg of each agent.

Protocol source ↗ · Conference abstract

Results · Original conference abstract
MeasureResultComparison, timing and statistics
Combination vs control18.8% longer survival timeReported p ≤ 0.05 vs control.
Metaprot vs control16.1% longer survival timeReported p ≤ 0.05 vs control.
Succinic acid vs control14.9% longer survival timeNo p value supplied.

The combination exceeded the Metaprot estimate by 2.7 percentage points. A difference between those arms and a synergistic interaction were not established.

Source for these results ↗ · Reviewed 2026-11-11

Population / setting
40 outbred white mice in four groups of ten.
Source reviewed
Original conference abstract and the reported comparisons checked.
Study limitations
  • The abstract gives no absolute survival times, uncertainty intervals, direct combination-versus-monotherapy test or formal interaction test.
  • Related proceedings versions should be treated as the same experiment.

Reviewed 2026-11-11.

Read the source ↗

Follow shared publications or research classes. These links do not establish equivalent effects between compounds.

Bemitil research ↗

1 shared source record

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

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