Sedatin & dermorphin analoguesСедатин / аналоги дерморфина
What is it?
A family of synthetic dermorphin-related peptides studied in tissue homeostasis, oxidative injury and opioid pharmacology.
Research context
A family of synthetic dermorphin-related peptides studied in tissue homeostasis, oxidative injury and opioid pharmacology.
What the studies found
in vitro · 2016
Primary rat pulmonary fibroblasts
Sedatin preserved selected oxidative-stress and nuclear measures in rat pulmonary fibroblasts. Naloxone partially reduced these effects, supporting opioid involvement in this assay.
Limit: Preclinical findings do not establish human benefit or safety.
Cytoprotective Effect of Peptide Sedatin, an Agonist of μ/δ-Opioid Receptors, on Primary Culture of Pulmonary Fibroblasts of Albino Rats under Conditions of Oxidative Stress. ↗animal · 2009
Mice; experimental gastric injury
Sedatin pretreatment reduced indomethacin-induced gastric injury in mice; the Arg-free comparator did not reproduce the same pattern.
Limit: Preclinical findings do not establish human benefit or safety.
Protective effect of dermorphin analogue sedatin on indomethacin-induced injury to the gastric mucosa. ↗animal · 2007
Newborn rats; myocardial tissue assays
Sedatin changed myocardial DNA-synthesis, nucleolar and oxidative measures in newborn rats. Its Arg-free analogue showed little effect in this experiment.
Limit: Preclinical findings do not establish human benefit or safety.
Effect of synthetic dermorphin analogues on tissue homeostasis in the myocardium of newborn albino rats. ↗Selected findings, not a systematic review or a treatment recommendation. Combination and related-preparation results cannot be attributed to this compound alone. See each source for access status and remaining limitations.
- Working classification
- Peptide research family
- Research collection
- Opioid-peptide cytoprotection · editorial grouping
- Institutional provenance
- Not established for this compound record
- Last evidence review
- Full evidence review pending; source-check scope appears with each publication below.
What do we know?
- Human research
- —No human treatment trial assessed for this family
- Study methods
- —Member-specific studies; patents and archival leads identified separately
- Independent replication
- —Independent replication not established by the records collected here
- Source access
- —Primary abstracts, selected full texts, patents and explicit retrieval targets
- Safety evidence
- —Cell and animal effects do not establish human safety; analogues may differ
These are independent review fields, not a rating. Missing evidence in this starter does not mean no research exists.
Inside this research family
Grouping supports navigation. It does not imply equivalent composition, mechanisms, effectiveness or safety.
| Member | Identity | What the source supports |
|---|---|---|
| Sedatin | Arg–Tyr–D-Ala–Phe–Gly | Patent-defined peptide with cell and animal tissue-injury research. Peptide, preparation and pharmaceutical composition — US6248716B1 ↗ |
| Arg-free comparator | Tyr–D-Ala–Phe–Gly | Did not reproduce all Sedatin findings in the linked animal experiments. |
| A10 / A17 / A43 | Historical laboratory-code series | A10: Tyr–D-Orn–Phe–Gly; A17: Arg–Tyr–D-Lys–Phe–Gly; A43: Arg–Tyr–D-Arg–Phe–D-Ala–NH₂. Transcription checked; original scan pending. Morphogenetic activity of dermorphin and its analogues in different cell populations ↗ |
Interpretation and open questions
The broad patent scaffold does not prove that every number between A10 and A43 corresponds to a tested molecule.
Tissue DNA-synthesis and oxidative markers are not demonstrated recovery benefits in people.
Linked sources
Explore the research map and unresolved leads ↗
Cytoprotective Effect of Peptide Sedatin, an Agonist of μ/δ-Opioid Receptors, on Primary Culture of Pulmonary Fibroblasts of Albino Rats under Conditions of Oxidative Stress.
Sazonova EN, Samarina EY, Lebed'ko OA, Maltseva IM, Timoshin SS · Bulletin of experimental biology and medicine
Sedatin preserved selected oxidative-stress and nuclear measures in rat pulmonary fibroblasts. Naloxone partially reduced these effects, supporting opioid involvement in this assay.
- Population / setting
- Primary rat pulmonary fibroblasts
- What was checked
- Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Limitations & review scope
- Preclinical findings do not establish human benefit or safety.
- Indexed abstract reviewed; full methods and independent replication require appraisal.
Source checked 2026-10-05. This is a source-linked record, not a completed evidence review.
Protective effect of dermorphin analogue sedatin on indomethacin-induced injury to the gastric mucosa.
Fleishman MY, Zhivotova EY, Lebedko OA, Deigin VI, Timoshin SS · Bulletin of experimental biology and medicine
Sedatin pretreatment reduced indomethacin-induced gastric injury in mice; the Arg-free comparator did not reproduce the same pattern.
- Population / setting
- Mice; experimental gastric injury
- What was checked
- Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Limitations & review scope
- Preclinical findings do not establish human benefit or safety.
- Indexed abstract reviewed; full methods and independent replication require appraisal.
Source checked 2026-10-05. This is a source-linked record, not a completed evidence review.
Effect of synthetic dermorphin analogues on tissue homeostasis in the myocardium of newborn albino rats.
Kriganovskaya SY, Lebed'ko OA, Sazonova EN, Timoshin SS, Molokanova LE · Bulletin of experimental biology and medicine
Sedatin changed myocardial DNA-synthesis, nucleolar and oxidative measures in newborn rats. Its Arg-free analogue showed little effect in this experiment.
- Population / setting
- Newborn rats; myocardial tissue assays
- What was checked
- Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Limitations & review scope
- Preclinical findings do not establish human benefit or safety.
- Indexed abstract reviewed; full methods and independent replication require appraisal.
Source checked 2026-10-05. This is a source-linked record, not a completed evidence review.
Peptide, preparation and pharmaceutical composition — US6248716B1
· Primary source linked above
The Sedatin patent documents Arg–Tyr–D-Ala–Phe–Gly and related peptide chemistry. Related scaffold claims in RU2067000C1 do not establish that every possible A-number was synthesized or tested.
- Population / setting
- Patent chemistry and experimental examples
- What was checked
- Selected original-source text checked; full methodological review pending.
Limitations & review scope
- No clinical benefit or regulatory approval inferred from patent grant.
Source checked 2026-10-05. This is a source-linked record, not a completed evidence review.
Morphogenetic activity of dermorphin and its analogues in different cell populations
· Dissertation transcription
· Dissertation; primary text transcription
The dissertation transcription identifies A10, A17, A43 and Sedatin as distinct synthetic analogues. Gastric and corneal DNA-synthesis responses differed across the tested peptides, arguing against a uniform tissue effect.
- Population / setting
- Rat tissue experiments; dissertation transcription
- What was checked
- Selected sequence table and tissue-response conclusions checked; original scan pending.
Limitations & review scope
- Original scan and underlying experiment overlap still require appraisal.
- Working codes are not marketed product identities; tissue markers do not establish human regeneration.
Source checked 2026-10-05. This is a source-linked record, not a completed evidence review.