COMPOUND RECORD / BINAVIT

BinavitБинавит

Recovery

Source linked

What the studies found

Animal research · 2026

B vitamins changed selected injury markers without significant tissue improvement

Creatinine and renal TBARS: Lower at both vitamin dosesVersus methotrexate alone
AST and hepatic TBARS: Lower only at the higher dose
Histopathology, ALT, urea and total thiol: No significant improvement

B1/B6/B12 combinations improved selected biochemical measures after methotrexate exposure. Both doses lowered creatinine and renal TBARS; only the higher dose lowered AST and hepatic TBARS. Neither dose significantly improved liver or kidney histopathology, ALT, urea or total thiol.

Study notes · methods, sources and limitations

Participants or model Male Wistar rats exposed to methotrexate; B1/B6/B12 combinations, not a verified Binavit-brand trial.

Low vitamin dose: B1/B6/B12: 16/16/0.16 mg/kg dailyIntraperitoneal, days 1–14; animal doses
High vitamin dose: B1/B6/B12: 32/32/0.32 mg/kg dailyIntraperitoneal, days 1–14; animal doses

Important limitations

This is class-level B-vitamin research in rats, not evidence for the Binavit brand or human methotrexate care. No vitamin-only group was included, and biochemical changes were not accompanied by significant tissue-level improvement.

Naunyn-Schmiedeberg's archives of pharmacology · Journal publication

Original source or citation ↗

Study results and tables ↗

Randomized study in people · 2017

[Evaluation of efficiency and safety of adding neuromultivit to basic therapy of vertebrogenic radiculopathy].

Pain/disability scales: Add-on arm favoredp<0.05
Adverse-event spectrum: Described as not significantly differentThe abstract nevertheless prints p<0.05; this inconsistency is not resolved

An open randomized trial reports greater improvement in pain and disability measures when Neuromultivit was added to basic therapy.

Study notes · methods, sources and limitations

Participants or model 100 patients with L5–S1 vertebrogenic radiculopathy

Design 100 L5–S1 radiculopathy patients in an open randomized add-on comparison: Neuromultivit plus basic care versus basic care.

Important limitations

Open treatment and background therapy limit attribution. Short-term symptom improvement is not direct proof of nerve regeneration. Neuromultivit is not Binavit; formulation, route and co-interventions require separate assessment.
Neuromultivit is the studied preparation; this is class-level context under Binavit, not direct Binavit efficacy.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · Journal publication

Original source or citation ↗

Study results and tables ↗

Animal research · 2012

Dexamethasone and vitamin B(12) synergistically promote peripheral nerve regeneration in rats by upregulating the expression of brain-derived neurotrophic factor.

B12 and dexamethasone experiments report functional, electrophysiological and myelinated-fiber changes alongside increased BDNF expression.

Study notes · methods, sources and limitations

Participants or model 96 male Wistar rats with sciatic-nerve injury

Important limitations

Animal combination research does not establish human nerve repair or a Binavit effect. This international study supplies mechanistic context, not Soviet provenance.

Archives of medical science : AMS · Journal publication

Original source or citation ↗

Study results and tables ↗

01 / OVERVIEW

About Binavit

Names in this research collection

B1/B6/B12 · Neurotropic B vitamins

Binavit is a Russian injectable B1/B6/B12 preparation with lidocaine. This page also serves as an umbrella for the broader B-vitamin peripheral-nerve research tradition, without treating every study as a trial of this brand.

Identity / background source ↗

Research background

An umbrella for Soviet and Russian B-vitamin nerve research. Product documentation, related-formulation trials, historical reports, animal experiments and clinical guidance retain separate evidence labels.

Compound class: B-vitamin research collection
Research collection: Related nootropics & combinations · editorial grouping
Research institutions: No institutional affiliation recorded
Source review: Review dates and the material assessed are listed with each publication below.

02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research Related-formulation trial and historical B12 report; direct Binavit evidence not established
Study methods Open trial, session summary and guideline evidence are distinguished
Independent replication Cross-brand findings are not assumed equivalent or independently replicated
Source access Manufacturer documentation, journal records, Russian PDF and guideline reproductions
Safety evidence Excess B6 can cause neuropathy; injectable-product risks require clinical assessment

Open a topic for the evidence assessment.

More findings, background and history

What remains unclear

Group assignment, comparators, planned outcomes, effect estimates, adverse events and possible participant overlap are key limits to interpreting the studies.

Human reports are linked; their presence does not establish effectiveness. Several publications can describe the same participants.

Browse original study records ↗

BINAVIT / B-VITAMIN RESEARCH COLLECTION

Peripheral nerves, metabolism and repair.

This section covers B-vitamin research across different periods and formulations. Each source identifies what was actually studied. Inclusion here does not mean the researchers used Binavit.

The product and the research class

The injectable product combines thiamine, pyridoxine, cyanocobalamin and lidocaine. Its prescribing document lists 100 mg B1, 100 mg B6, 1 mg B12 and 20 mg lidocaine per 2 mL. Product identity does not establish clinical benefit; other brands, oral formulations and individual vitamins are not assumed interchangeable.

Manufacturer and prescribing document ↗

B1 / thiamine

Energy and carbohydrate metabolism provide the biological context for nerve-function research.

B6 / pyridoxine

Amino-acid and neurotransmitter metabolism are relevant to nerve function. Excess exposure can itself cause sensory neuropathy.

B12 / cobalamin

Nucleotide and myelin metabolism motivate research into nerve injury. Biological necessity does not prove an added benefit above adequate status.

B6 safety reference · NIH ↗

The early Soviet record

A 1958 B1 publication is indexed, but its methods and results remain unreviewed. A 1959 Vitaminology session summary describes B12 research in 50 people with severed arm nerves. It reports favorable recovery, without enough detail to establish the strength of the comparison.

1958 bibliographic record ↗ · 1959 session report ↗

Clinical outcomes versus regeneration

The 2017 Neuromultivit trial studied add-on treatment in radiculopathy. Pain and disability outcomes answer a different question from structural nerve repair. Experimental B12/dexamethasone work in rats measured nerve fibers, conduction and BDNF; those findings cannot be transferred directly to humans or to Binavit.

Radiculopathy trial ↗ · Experimental nerve repair ↗ · Russian literature review ↗

Occupational and toxic neuropathy

The 2024 vibration-disease guidance names B-vitamin combinations for extremity polyneuropathy. The 2025 toxic-neurology guidance names B1/B6/B12 for toxic polyneuropathy. Both relevant recommendations carry C / level 5 ratings. They document clinical guidance, not high-certainty Binavit efficacy or protection from workplace hazards.

Vibration guidance ↗ · Toxic-neurology guidance ↗

Sources, PDFs and documents to locate

Source text checked · appraisal incomplete

Binavit injectable: manufacturer catalogue and prescribing information

Catalogue confirms B1/B6/B12 plus lidocaine. The linked prescribing document provides composition and safety information; neither is a clinical efficacy trial.

Source and access details ↗

Russian PDF located · full appraisal pending

Neuromultivit radiculopathy trial — full Russian paper

Full-text access companion to bin-29171487; the same trial, not a second cohort.

Source and access details ↗

Source text checked · appraisal incomplete

Vibration exposure / vibration disease: Russian clinical recommendations

The polyneuropathy section names B1/B6/B12 and a lidocaine-containing combination, rated C / evidence level 5. Documents practice guidance, not strong brand-specific trial evidence. Original cited studies require review.

Source and access details ↗

Source text checked · appraisal incomplete

Toxic and metabolic lesions of the nervous system: Russian clinical recommendations

The toxic-polyneuropathy section names pyridoxine/thiamine/cyanocobalamin, rated C / evidence level 5. Guidance is not a controlled Binavit trial or evidence for prevention of toxic exposure.

Source and access details ↗

Bibliographic leads · original reports pending

Earlier Russian clinical B-vitamin literature

Acquisition targets include the 2001 diabetic-neuropathy report, 2009 Milgamma radiculopathy comparison and 2011 Combilipen/NSAID report. Different formulations and adjunctive treatments must be kept separate.

Source and access details ↗

Original records not recovered

Occupational, toxic and neuromuscular evidence: remaining source targets

Retrieve the reported 198-worker multimodal comparison, dysphonia guidance and underlying references in occupational/toxic guidelines. No numerical treatment effect is assigned.

Source and access details ↗

B-300: a separate experimental combination ↗

Educational only; not medical advice. Seek a qualified healthcare professional for any condition. This collection provides no injection instructions or personal regimen. Direct Binavit-branded controlled evidence has not been established in this collection.

03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2026 · Effects of vitamin B1/B6/B12 complex on methotrexate-induced hepatorenal toxicity in a short-term acute rat modelLow vitamin dose: B1/B6/B12: 16/16/0.16 mg/kg daily

2026Animal / experimentalEnglish abstract

Effects of vitamin B1/B6/B12 complex on methotrexate-induced hepatorenal toxicity in a short-term acute rat model

· Journal publication

Toprak-Semiz A, Deniz E, Topçu A, Mataracı Karakaş S, Öztürk Ç, Yavuz-Bedir E · Naunyn-Schmiedeberg's archives of pharmacology

Results and tables

Reported findings and study design

Dose, route and schedule

B1/B6/B12 intraperitoneally daily on days 1–14 at 16/16/0.16 or 32/32/0.32 mg/kg; methotrexate 20 mg/kg intraperitoneally once on day 7. Rat study methods; formulation not established as Binavit.

Protocol source ↗ · Indexed abstract checked

Results · Indexed abstract checked
Measure	Result	Comparison, timing and statistics
Low vitamin dose	B1/B6/B12: 16/16/0.16 mg/kg daily	Intraperitoneal, days 1–14; animal doses
High vitamin dose	B1/B6/B12: 32/32/0.32 mg/kg daily	Intraperitoneal, days 1–14; animal doses
Creatinine and renal TBARS	Lower at both vitamin doses	Versus methotrexate alone
AST and hepatic TBARS	Lower only at the higher dose
Histopathology, ALT, urea and total thiol	No significant improvement

This is class-level B-vitamin research in rats, not evidence for the Binavit brand or human methotrexate care. No vitamin-only group was included, and biochemical changes were not accompanied by significant tissue-level improvement.

Source for these results ↗ · Reviewed 2026-10-31

Population / setting: Male Wistar rats exposed to methotrexate; B1/B6/B12 combinations, not a verified Binavit-brand trial.
Source reviewed: Primary publication metadata and indexed abstract checked through Europe PMC on 31 October 2026. No unavailable effect sizes inferred.

Study limitations

This is class-level B-vitamin research in rats, not evidence for the Binavit brand or human methotrexate care. No vitamin-only group was included, and biochemical changes were not accompanied by significant tissue-level improvement.

Reviewed 2026-10-31.

Read the source ↗

2017 · [Evaluation of efficiency and safety of adding neuromultivit to basic therapy of vertebrogenic radiculopathy].Pain/disability scales: Add-on arm favored

2017Randomized trialEnglish abstract

[Evaluation of efficiency and safety of adding neuromultivit to basic therapy of vertebrogenic radiculopathy].

Neuromultivit B1/B6/B12 combination; class-level context · Journal publication

Khabirov FA, Khaibullin TI, Granatov EV · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

An open randomized trial reports greater improvement in pain and disability measures when Neuromultivit was added to basic therapy.

Results and tables

Reported findings and study design

100 L5–S1 radiculopathy patients in an open randomized add-on comparison: Neuromultivit plus basic care versus basic care.

Results · Previously retrieved indexed abstract; numerical statements checked against the saved source text
Measure	Result	Comparison, timing and statistics
Pain/disability scales	Add-on arm favored	p<0.05
Adverse-event spectrum	Described as not significantly different	The abstract nevertheless prints p<0.05; this inconsistency is not resolved

Neuromultivit is the studied preparation; this is class-level context under Binavit, not direct Binavit efficacy.

Source for these results ↗ · Reviewed 2026-10-29

Population / setting: 100 patients with L5–S1 vertebrogenic radiculopathy
Source reviewed: Indexed citation and abstract checked; complete methods and risk-of-bias appraisal pending.

Study limitations

Open treatment and background therapy limit attribution. Short-term symptom improvement is not direct proof of nerve regeneration.
Neuromultivit is not Binavit; formulation, route and co-interventions require separate assessment.

Reviewed 2026-09-30.

Read the source ↗

2012 · Dexamethasone and vitamin B(12) synergistically promote peripheral nerve regeneration in rats by upregulating the expression of brain-derived neurotrophic factor.

2012Animal / experimentalEnglish abstract

Dexamethasone and vitamin B(12) synergistically promote peripheral nerve regeneration in rats by upregulating the expression of brain-derived neurotrophic factor.

Vitamin B12 with or without dexamethasone; not Binavit · Journal publication

Sun H, Yang T, Li Q, Zhu Z, Wang L, Bai G, Li D, Li Q, Wang W · Archives of medical science : AMS

B12 and dexamethasone experiments report functional, electrophysiological and myelinated-fiber changes alongside increased BDNF expression.

Population / setting: 96 male Wistar rats with sciatic-nerve injury
Source reviewed: Indexed citation and abstract checked; complete methods and risk-of-bias appraisal pending.

Study limitations

Animal combination research does not establish human nerve repair or a Binavit effect. This international study supplies mechanistic context, not Soviet provenance.

Reviewed 2026-09-30.

Read the source ↗

1958 · [Effect of phenatine, vitamin B1, mixture of phenate and vitamin B1 and dibazole on regeneration of the peripheral nerves].

1958Study design unresolvedBibliographic record

[Effect of phenatine, vitamin B1, mixture of phenate and vitamin B1 and dibazole on regeneration of the peripheral nerves].

Historical B1 and other-agent comparisons; not Binavit · Journal publication

GENERALOV VI · Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)

A 1958 publication links thiamine-containing interventions with peripheral-nerve regeneration research.

Population / setting: Population and experimental design not established from the indexed citation
Source reviewed: Indexed citation and abstract checked; complete methods and risk-of-bias appraisal pending.

Study limitations

No abstract was available. Outcomes, model and effect sizes cannot be inferred from the title.

Reviewed 2026-09-30.

Read the source ↗

1959 · Second scientific session of the Institute of Vitaminology, Ministry of Health of the USSR

1959Study design unresolvedRussian source · see review scope

Second scientific session of the Institute of Vitaminology, Ministry of Health of the USSR

Cobalamin / B12; historical research · Journal publication

Session report; individual report attributed to S. V. Andreev, A. A. Znachkova and Yu. S. Chechulin · Kazan Medical Journal 40(5), 1959

The historical report describes earlier and more complete functional recovery with cobalamin than with other stimulatory treatments.

Population / setting: A session summary describes 50 patients with severed arm nerves
Source reviewed: Publisher session summary checked; original patient-level report not recovered.

Study limitations

Conference-session account, not a fully appraised controlled trial. Allocation, comparator details and denominators per group are unavailable here.
This predates the Binavit product and cannot establish its effectiveness.

Reviewed 2026-09-30.

Read the source ↗

2024 · B vitamins and diseases of the peripheral nervous system

2024ReviewEnglish abstract

B vitamins and diseases of the peripheral nervous system

B-vitamin class and related formulations · Journal publication

P. R. Kamchatnov, A. V. Chugunov, A. A. Kabanov, A. Yu. Kazakov, N. D. Safronova · S.S. Korsakov Journal of Neurology and Psychiatry 124(5):75–82

Maps deficiency, neurotropic-vitamin mechanisms and clinical literature across formulations.

Population / setting: Review of peripheral-nerve disease and B-vitamin literature
Source reviewed: Publisher citation, abstract and bibliography checked; underlying studies not all appraised.

Study limitations

A narrative review is not a new trial. Cited mechanisms and formulations cannot be treated as direct Binavit evidence.
The underlying clinical reports and any participant overlap are unverified.

Reviewed 2026-09-30.

Read the source ↗

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗