Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)
Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN, Baratashvili NA, Lezhava TA · 2012 · Georgian medical news 2012
Reported findings and study design
Prostamax increased sister-chromatid exchanges from 5.9 ± 0.2 to 12.0 ± 0.28 per cell and silver-positive nucleolar organizer regions from 0.95 to 2.5 per cell. These are chromatin assays, not prostate-symptom outcomes.
Cultured cells from donors aged 75–86 years.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Sister-chromatid exchanges per cell | 12.0 ± 0.28 versus 5.9 ± 0.2 | Prostamax-exposed versus intact cells |
| Silver-positive nucleolar organizer regions | 2.5 versus 0.95 per cell | Exposed versus intact cells |
An increase in sister-chromatid exchange is a cellular observation, not inherently a clinical benefit. Donor number and long-term consequences are not supplied in the abstract.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- An increase in sister-chromatid exchange is a cellular observation, not inherently a clinical benefit. Donor number and long-term consequences are not supplied in the abstract.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Related-report group: khavinson-lymphocyte-chromatin-program. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original-publication metadata and indexed abstract checked in Europe PMC. No unavailable full-text figures inferred.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN, Baratashvili NA, Lezhava TA. Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro) Georgian medical news 2012 2012.
Molekul research summary: https://molekul.io/research/thin-23221144. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry