Study of the neuroprotective effect of NT-3 dipeptide mimetics GTS-301 and GTS-302 on an experimental model of ischemic stroke
D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva · 2026 · Pharmacokinetics and Pharmacodynamics. 2026;(1):12–19
What does this source report?
GTS-302 reduced infarct volume by 39% and improved the day-three neurological measure; GTS-301 was inactive in this experiment.
- Population and setting
- Rats with middle cerebral artery occlusion
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian / English abstract
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Animal experiment, not evidence of benefit in human stroke.
- Full methods, sample size and risk of bias require review.
- This is a separate stroke paper; the correction to an earlier NT-3 withdrawal study does not resolve or invalidate this paper automatically.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Deposited abstract reviewed
Source access and review scope
Publisher-deposited abstract and metadata reviewed through Crossref; publisher website could not be retrieved.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Cite and trace this record
Original source: D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva. Study of the neuroprotective effect of NT-3 dipeptide mimetics GTS-301 and GTS-302 on an experimental model of ischemic stroke Pharmacokinetics and Pharmacodynamics. 2026;(1):12–19 2026.
Molekul research summary: https://molekul.io/research/stroke-nt3-2026. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry