Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats
Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB · 2016 · Drug design, development and therapy · PMID 27843294
What does this source report?
GSB-106 and GSB-214 reduced infarct volume by approximately 66% and 28%, respectively, in this experiment.
- Population and setting
- Rat middle cerebral artery occlusion plus HT-22 signaling assays
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- English
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Animal results do not establish benefit or comparative potency in people.
- Effects are compound-specific and cannot be assigned to all BDNF mimetics.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Indexed citation and abstract reviewed via Europe PMC / PubMed; full methods and risk of bias not comprehensively appraised.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.2147/dddt.s118768
Cite and trace this record
Original source: Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB. Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats Drug design, development and therapy · PMID 27843294 2016.
Molekul research summary: https://molekul.io/research/stroke-27843294. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
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