PRIMULA: Rumalon in persistent knee osteoarthritis pain
A. E. Karateev, L. I. Alekseeva, A. M. Lila, et al. · 2018 · Consilium Medicum 20(9), 51–57
Indexed 2026-11-12.
Reported findings and study design
Reported findings
Open-label series with assessments at weeks 8 and 12. The Russian protocols used 25 intramuscular injections, starting with 0.3 and 0.5 mL, then 1 mL per injection. The main text specifies three maintenance injections per week.
Dose, route and schedule
Open-label series with assessments at weeks 8 and 12. The Russian protocols used 25 intramuscular injections, starting with 0.3 and 0.5 mL, then 1 mL per injection. The main text specifies three maintenance injections per week.
Protocol source ↗ · Original Russian article, full methods and results
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Pain at 12 weeks | Visual analog pain score fell 34.6% and WOMAC pain fell 37.2% from baseline (both p<0.001). | |
| Function and stiffness at 12 weeks | WOMAC functional impairment fell 30.0%, stiffness 30.4% and the total score 32.4% from baseline. | |
| Medication use and adverse events | 31.7% stopped NSAIDs. Adverse events were reported in 1.8%, with no resulting interruptions of Rumalon. |
The study had no comparison arm. Changes from baseline include the effects of concurrent care and time.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The study had no comparison arm. Changes from baseline include the effects of concurrent care and time.
Source access
Original Russian article, full methods and results
Source reviewed 2026-11-12.
Citation and original source
Original source: A. E. Karateev, L. I. Alekseeva, A. M. Lila, et al.. PRIMULA: Rumalon in persistent knee osteoarthritis pain Consilium Medicum 20(9), 51–57 2018.
Molekul research summary: https://molekul.io/research/rumalon-primula-2018. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry