GLADIOLUS observational study of Rumalon in osteoarthritis
L. I. Alekseeva, A. E. Karateev, E. Yu. Pogozheva, V. N. Amirdzhanova, E. S. Filatova, V. A. Nesterenko · 2020 · Modern Rheumatology Journal 14(2), 76–83
Indexed 2026-11-12.
Reported findings and study design
Reported findings
Russian multicenter retrospective analysis of routine care over 12 weeks. The Russian protocols used 25 intramuscular injections, starting with 0.3 and 0.5 mL, then 1 mL per injection. Maintenance injections were given three times per week. Diacerein was 100 mg/day in the combination subgroup. Clinicians could use additional care.
Dose, route and schedule
Russian multicenter retrospective analysis of routine care over 12 weeks. The Russian protocols used 25 intramuscular injections, starting with 0.3 and 0.5 mL, then 1 mL per injection. Maintenance injections were given three times per week. Diacerein was 100 mg/day in the combination subgroup. Clinicians could use additional care.
Protocol source ↗ · Original Russian article
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Pain with movement at 12 weeks | Median 6 to 2 on a 0–10 scale. Pain at rest fell from 4 to 1, and functional impairment fell from 5 to 1. | |
| NSAID use | 68.1% reportedly stopped taking NSAIDs. | |
| Reported adverse events | Skin allergic reactions in 0.3% and moderate injection-site pain in 0.37%. Gastrointestinal and cardiovascular events were reported in 8% and 6%, respectively. |
All patients received Rumalon. Treatment selection and concurrent care can explain some of the change from baseline.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- All patients received Rumalon. Treatment selection and concurrent care can explain some of the change from baseline.
Source access
Original Russian article
Source reviewed 2026-11-12.
Citation and original source
Original source: L. I. Alekseeva, A. E. Karateev, E. Yu. Pogozheva, V. N. Amirdzhanova, E. S. Filatova, V. A. Nesterenko. GLADIOLUS observational study of Rumalon in osteoarthritis Modern Rheumatology Journal 14(2), 76–83 2020.
Molekul research summary: https://molekul.io/research/rumalon-gladiolus-2020. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry