Rumalon with or without diacerein in a Russian multicenter knee osteoarthritis trial
L. I. Alekseeva, A. M. Lila, E. P. Sharapova, E. A. Taskina, et al. · 2022 · Therapy, issue 2, pp. 6–18
Indexed 2026-11-12.
Reported findings and study design
Reported findings
The authors report random assignment, eight months of treatment and two months of follow-up. The Russian protocols used 25 intramuscular injections, starting with 0.3 and 0.5 mL, then 1 mL per injection. The 1 mL injections were given on alternate days and the course was repeated at six months. The combination group received diacerein 50 mg daily for one month, then 50 mg twice daily for seven months.
Dose, route and schedule
The authors report random assignment, eight months of treatment and two months of follow-up. The Russian protocols used 25 intramuscular injections, starting with 0.3 and 0.5 mL, then 1 mL per injection. The 1 mL injections were given on alternate days and the course was repeated at six months. The combination group received diacerein 50 mg daily for one month, then 50 mg twice daily for seven months.
Protocol source ↗ · Original Russian article, methods and results
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| WOMAC pain at the end of treatment | Median scores fell from 198 to 110 mm with combination therapy and from 209 to 112 mm with Rumalon alone. | |
| Pain on movement | Both groups improved on the visual analog scale. The authors found no between-group difference on this measure. | |
| Ultrasound-detected synovitis | Relative risk 0.51 with combination therapy versus Rumalon alone at the end of treatment (95% CI 0.28–0.92, p=0.04). | |
| Adverse events | Four combination participants and one Rumalon-only participant reported an event. One combination participant withdrew after hand-joint swelling. |
Both arms received Rumalon. The trial compares adding diacerein with continuing Rumalon alone. Baseline visual analog pain was higher in the combination group.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- Both arms received Rumalon. The trial compares adding diacerein with continuing Rumalon alone. Baseline visual analog pain was higher in the combination group.
Source access
Original Russian article, methods and results
Source reviewed 2026-11-12.
Citation and original source
Original source: L. I. Alekseeva, A. M. Lila, E. P. Sharapova, E. A. Taskina, et al.. Rumalon with or without diacerein in a Russian multicenter knee osteoarthritis trial Therapy, issue 2, pp. 6–18 2022.
Molekul research summary: https://molekul.io/research/rumalon-diacerein-2022. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry