Three-year Russian comparison of Rumalon in workers with knee osteoarthritis
L. I. Alekseeva, A. N. Karyakin, A. V. Smirnov, L. I. Benevolenskaya · 1997 · Terapevticheskii Arkhiv, issue 5, pp. 64–66
Indexed 2026-11-12.
Reported findings and study design
Reported findings
Open prospective comparison. Rumalon was given as 2 mL intramuscularly twice weekly for 15 injections per course, two courses per year for three years. Both groups could receive ibuprofen and physiotherapy. Ten treated participants and five controls withdrew.
Dose, route and schedule
Open prospective comparison. Rumalon was given as 2 mL intramuscularly twice weekly for 15 injections per course, two courses per year for three years. Both groups could receive ibuprofen and physiotherapy. Ten treated participants and five controls withdrew.
Protocol source ↗ · Original Russian article, pp. 64–66
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Pain with walking | At the start of year two, the paper reports 0.69 versus 1.41 points with Rumalon and control (p<0.01). | |
| Joint function | The Lequesne index differed at 18 months (p<0.05). Knee range of motion favored the treated group (p<0.04). | |
| Radiographic progression | The authors found no statistically significant group difference. | |
| Allergic reaction | One participant discontinued Rumalon during the third course after an allergic reaction. |
Open treatment, unequal group sizes, withdrawals and concurrent care limit the symptom comparison.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- Open treatment, unequal group sizes, withdrawals and concurrent care limit the symptom comparison.
Source access
Original Russian article, pp. 64–66
Source reviewed 2026-11-12.
Citation and original source
Original source: L. I. Alekseeva, A. N. Karyakin, A. V. Smirnov, L. I. Benevolenskaya. Three-year Russian comparison of Rumalon in workers with knee osteoarthritis Terapevticheskii Arkhiv, issue 5, pp. 64–66 1997.
Molekul research summary: https://molekul.io/research/rumalon-alekseeva-1997. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry