Cytoprotective effect of non-opioid leu-enkephalin analogue in primary culture of pulmonary fibroblasts in oxidative stress
E. N. Sazonova, O. A. Lebedko, G. A. Denisyuk, K. V. Zhmerenetskiy, V. A. Dobrykh · 2019 · Primary source linked above
What does this source report?
NALE reduced oxidative-stress and nucleolar changes in pulmonary fibroblasts. The paper explicitly gives Phe–D-Ala–Gly–Phe–Leu–Arg; its suggested NOP mechanism was a hypothesis.
- Population and setting
- Primary pulmonary fibroblasts
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- See source; English abstract or translated patent text where available
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- In-vitro surrogate outcomes, not clinical recovery.
- Later receptor-blockade work qualifies the proposed mechanism.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Selected text reviewed
Source access and review scope
Selected original-source text checked; full methodological review pending.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.17816/KMJ2019-153
Cite and trace this record
Original source: E. N. Sazonova, O. A. Lebedko, G. A. Denisyuk, K. V. Zhmerenetskiy, V. A. Dobrykh. Cytoprotective effect of non-opioid leu-enkephalin analogue in primary culture of pulmonary fibroblasts in oxidative stress Primary source linked above 2019.
Molekul research summary: https://molekul.io/research/rp-nale-2019. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry