Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk

What does this source report?

GSB-106 showed acute antidepressant-like activity; GSB-214 also became active with repeated administration. GTS-201 was inactive in this forced-swim comparison. Different signaling patterns did not yield interchangeable behavioral effects.

Population and setting

Rodent forced-swim tests; comparison with cell-signaling results

Evidence type

Animal / experimental

Preparation

See the original report; formulation details require verification.

Source language

See source; English abstract or translated patent text where available

Title provenance

Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

• Behavioral proxies are not a clinical diagnosis or treatment outcome.
• Different schedules and models limit cross-compound comparisons.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Review depth: Selected text reviewed

Source access and review scope

Selected original-source text checked; full methodological review pending.

Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.3390/ph15030284

Cite and trace this record

Original source: Author unconfirmed. Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk Primary source linked above 2022.

Molekul research summary: https://molekul.io/research/rp-bdnf-patterns-2022. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

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