Role of Amino Acid Arginine and Nitric Oxide in Mechanisms of Cytoprotective Effect of Non-Opiate Leu-Enkephalin Analogue In Vitro.

What does this source report?

NALE and the C-terminal Gly comparator peptide G reduced oxidative-injury markers. NO-synthase inhibition did not remove protection, arguing against an essential role for terminal Arg or NO-synthase activation in this cell model.

Population and setting

Primary pulmonary fibroblast cultures

Evidence type

In vitro

Preparation

See the original report; formulation details require verification.

Source language

English indexed abstract; original language: eng

Title provenance

Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

• Preclinical findings do not establish human benefit or safety.
• Indexed abstract reviewed; full methods and independent replication require appraisal.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Review depth: Abstract reviewed

Source access and review scope

Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.

Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.1007/s10517-021-05374-2

Cite and trace this record

Original source: Sazonova EN, Lebed'ko OA, Pinaeva OG, Tsimbalist NA, Kupriyanova DA, Tarasov PK, Malofey YB. Role of Amino Acid Arginine and Nitric Oxide in Mechanisms of Cytoprotective Effect of Non-Opiate Leu-Enkephalin Analogue In Vitro. Bulletin of experimental biology and medicine 2021.

Molekul research summary: https://molekul.io/research/rp-34855076. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

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