Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Gudasheva TA, Povarnina PY, Antipova TA, Firsova YN, Konstantinopolsky MA, Seredenin SB · 2015 · Journal of biomedical science
What does this source report?
GK-2 and GK-6 both increased TrkA phosphorylation, but GK-6 additionally recruited ERK, promoted PC12 differentiation and lowered rat pain thresholds. GK-2 favored AKT signaling in these assays and did not produce the same hyperalgesia.
- Population and setting
- HT-22 and PC12 cells; rat tail-flick experiments
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language: eng
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Preclinical findings do not establish human benefit or safety.
- Indexed abstract reviewed; full methods and independent replication require appraisal.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Primary publication metadata and indexed abstract checked via Europe PMC; full methodological review pending.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Gudasheva TA, Povarnina PY, Antipova TA, Firsova YN, Konstantinopolsky MA, Seredenin SB. Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction. Journal of biomedical science 2015.
Molekul research summary: https://molekul.io/research/rp-26642930. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry