Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia
Semenova TP, Kozlovskaya MM, Zuikov AV, Kozlovskii II, Zakharova NM, Andreeva LA · 2008 · Neuroscience and behavioral physiology. 2008;38(2):203. PMID 18197389
Adult offspring treatment · Pregnancy and offspring evidence review ↗
Reported findings and study design
Reported findings
Selank given to adult offspring increased sensory attention by a reported factor of 2–3 and facilitated learning 1.5-fold (both p<0.01). This was treatment after prenatal injury, not administration to pregnant mothers.
Adult-offspring behavioral and brain serotonin/noradrenaline assessment after prenatal hypoxia; Selank 300 µg/kg intraperitoneally.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Sensory attention | Reported 2–3-fold increase | p<0.01; no n or confidence interval supplied |
| Learning | Reported 1.5-fold facilitation | p<0.01 |
| Monoamine balance | Investigative behavior and serotonin/noradrenaline balance reportedly restored; exact concentrations absent |
Adult offspring treatment cannot establish fetal safety of maternal Selank. The 2008 English article translates the 2006 Russian paper, PMID 17385425; these are not independent replications. Sample sizes, blinding, litter handling and numerical raw scores are unavailable in the checked abstract.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Adult offspring treatment cannot establish fetal safety of maternal Selank.
- The 2008 English article translates the 2006 Russian paper, PMID 17385425; these are not independent replications.
- Sample sizes, blinding, litter handling and numerical raw scores are unavailable in the checked abstract.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publication record and available text
Review depth: Indexed original abstract; full methods and outcome tables not recovered
Related-report group: selank-prenatal-hypoxia-2006-translation-2008. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed original abstract; full methods and outcome tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Semenova TP, Kozlovskaya MM, Zuikov AV, Kozlovskii II, Zakharova NM, Andreeva LA. Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia Neuroscience and behavioral physiology. 2008;38(2):203. PMID 18197389 2008.
Molekul research summary: https://molekul.io/research/pregnancy-selank-adult-offspring-2008. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry