Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis
Graf AV, Maklakova AS, Krushinskaya YV, Sokolova NA · 2006 · Bulletin of experimental biology and medicine. 2006;142(1):32-4. PMID 17369896
Postnatal offspring treatment · Pregnancy and offspring evidence review ↗
Reported findings and study design
Narrative findings; numerical extraction incomplete
Postnatal Pro-Gly-Pro reportedly prevented delayed behavioral effects in adult females and most effects in males. Delayed physical development persisted in males. The mothers were not given PGP in this experiment.
Intranasal Pro-Gly-Pro to pups on postnatal days 13–15, 1 mg/kg; adult physical development, spontaneous behavior and training evaluated.
Dose, route and schedule
Pro-Gly-Pro 1 mg/kg intranasally to pups on postnatal days 13–15, following maternal hypoxia on gestation days 9–10. Research description, not human-use advice.
Protocol source ↗ · Indexed original abstract; full methods and outcome tables not recovered
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Female offspring | Authors report prevention of the measured negative behavioral consequences | |
| Male offspring: residual deficit | Most measured effects improved, but delayed physical development persisted |
Treatment was given to offspring after birth; this does not test maternal PGP exposure or fetal safety. Sample sizes, numerical scores, masking and litter-level analyses unavailable in the checked abstract. Sex-specific qualitative results are not quantified effect estimates.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Treatment was given to offspring after birth; this does not test maternal PGP exposure or fetal safety.
- Sample sizes, numerical scores, masking and litter-level analyses unavailable in the checked abstract. Sex-specific qualitative results are not quantified effect estimates.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publication record and available text
Review depth: Indexed original abstract; full methods and outcome tables not recovered
Related-report group: pregnancy-pgp-offspring-2006. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed original abstract; full methods and outcome tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Graf AV, Maklakova AS, Krushinskaya YV, Sokolova NA. Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis Bulletin of experimental biology and medicine. 2006;142(1):32-4. PMID 17369896 2006.
Molekul research summary: https://molekul.io/research/pregnancy-pgp-offspring-2006. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry