Correction of Negative Effect of Antenatal Hypoxia on Liver Tissue Homeostasis in Newborn Albino Rats with Opioid Peptides
Pinaeva OG, Sazonova EN, Lebed'ko OA, Timoshin SS · 2016 · Bulletin of experimental biology and medicine. 2016;162(2):203. PMID 27909965
Postnatal offspring treatment · Pregnancy and offspring evidence review ↗
Reported findings and study design
Narrative findings; numerical extraction incomplete
Neonatal Dalargin reportedly normalized liver growth/proliferation and nucleolar measures after prenatal hypoxia. The non-opioid analogue did not normalize all measures. Both reduced oxidative-stress indices; neither was administered to pregnant animals in this study.
Dalargin or a non-opiate Leu-enkephalin analogue, 100 µg/kg on postnatal days 2–6; day-7 liver growth, proliferation, nucleolar and redox assays.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Dalargin | Reported normalization of gravimetric, proliferation and hepatocyte nucleolar measures | |
| Non-opioid analogue: incomplete effect | Gravimetric and nucleolar parameters not normalized; proliferating-cell pool increased | Related analogue is not Dalargin |
| Redox outcomes | Both preparations reduced free-radical oxidation and improved antioxidant defenses; numerical effects unavailable |
Postnatal animal treatment, not maternal administration or human neonatal efficacy. Abstract gives no group n, exact numerical effects, comprehensive safety series or proof of normal adult liver function. The related analogue’s exact preparation must be verified separately before assigning its results to a specific NALE formulation.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Postnatal animal treatment, not maternal administration or human neonatal efficacy.
- Abstract gives no group n, exact numerical effects, comprehensive safety series or proof of normal adult liver function.
- The related analogue’s exact preparation must be verified separately before assigning its results to a specific NALE formulation.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publication record and available text
Review depth: Indexed original abstract; full methods and outcome tables not recovered
Related-report group: pregnancy-dalargin-neonatal-liver-2016. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed original abstract; full methods and outcome tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Pinaeva OG, Sazonova EN, Lebed'ko OA, Timoshin SS. Correction of Negative Effect of Antenatal Hypoxia on Liver Tissue Homeostasis in Newborn Albino Rats with Opioid Peptides Bulletin of experimental biology and medicine. 2016;162(2):203. PMID 27909965 2016.
Molekul research summary: https://molekul.io/research/pregnancy-dalargin-neonatal-liver-2016. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry