RESTORE ME: anhydrous enol-oxaloacetate trial
Cash A et al. · 2024 · Frontiers in Neurology
Indexed 2026-11-12.
Reported findings and study design
Reported findings
Double-blind trial of anhydrous enol-oxaloacetate 1,000 mg twice daily or rice flour for three months. The designated primary fatigue measure was the Chalder score.
Dose, route and schedule
Double-blind trial of anhydrous enol-oxaloacetate 1,000 mg twice daily or rice flour for three months. The designated primary fatigue measure was the Chalder score.
Protocol source ↗ · Original source
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Chalder fatigue at three months | Fatigue fell 27% from baseline with oxaloacetate. The end-of-study between-group comparison gave p=0.057. | |
| Responder analysis | The authors reported more participants achieving a greater than 25% reduction versus control (p<0.05). |
The lead author was an officer of the company funding and commercializing the formulation. The primary between-group comparison was inconclusive at the conventional 0.05 threshold.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The lead author was an officer of the company funding and commercializing the formulation. The primary between-group comparison was inconclusive at the conventional 0.05 threshold.
Related publications may cover the same research program or participants.
Source access
Double-blind trial of anhydrous enol-oxaloacetate 1,000 mg twice daily or rice flour for three months. The designated primary fatigue measure was the Chalder score.
Source reviewed 2026-11-12.
Citation and original source
Original source: Cash A et al.. RESTORE ME: anhydrous enol-oxaloacetate trial Frontiers in Neurology 2024.
Molekul research summary: https://molekul.io/research/oxaloacetate-restore-me-2024. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry