Spinorphin Ameliorates Nitroglycerin-Induced Migraine-Like Responses and Trigeminovascular Neuroinflammation Potentially Through Opioid Receptor-Mediated Mechanisms
Demir C, Torun IE, Baranoglu Kilinc Y, Kilinc E · 2026 · The European journal of neuroscience 64(8)
Published 2026-10. Indexed 2026-10-25.
Reported findings and study design
Spinorphin reduced mechanical hypersensitivity, c-Fos, CGRP and meningeal mast-cell degranulation in a rat migraine model. Nalmefene attenuated these effects. In ex vivo preparations, Spinorphin reduced capsaicin-evoked CGRP release and enhanced sumatriptan’s inhibitory effect on that endpoint.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Migraine-like responses | Mechanical hypersensitivity and CGRP-related measures reduced | Rat model |
| Opioid-receptor involvement | Effects attenuated by nalmefene | |
| Sumatriptan combination | Greater inhibition of capsaicin-evoked CGRP release | Ex vivo endpoint; not human combination efficacy |
Experimental rat and ex vivo findings, not a human migraine trial. A combined effect on CGRP release is not established clinical synergy with sumatriptan. These are Spinorphin results, not results for every myelopeptide.
Source for the extracted data ↗ · Checked 2026-10-31
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Experimental rat and ex vivo findings, not a human migraine trial. A combined effect on CGRP release is not established clinical synergy with sumatriptan. These are Spinorphin results, not results for every myelopeptide.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Primary publication metadata and indexed abstract checked through Europe PMC on 31 October 2026. No unavailable effect sizes inferred.
Recorded source-check date: 2026-10-31. This date does not imply a completed systematic review.
Source type: Journal publication
Open original source or index record ↗
DOI: 10.1111/ejn.70728
Citation and original source
Original source: Demir C, Torun IE, Baranoglu Kilinc Y, Kilinc E. Spinorphin Ameliorates Nitroglycerin-Induced Migraine-Like Responses and Trigeminovascular Neuroinflammation Potentially Through Opioid Receptor-Mediated Mechanisms The European journal of neuroscience 64(8) 2026.
Molekul research summary: https://molekul.io/research/oct31-42919102. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry