Spinorphin Attenuates Acute Experimental Seizures and Associated Neurochemical Alterations: Possible Involvement of Opioid Receptors
Torun IE, Baranoglu Kilinc Y, Kilinc E, Ankarali S · 2026 · Neurochemical research 51(6)
Published 2026-10-20. Indexed 2026-10-21.
Reported findings and study design
Spinorphin reduced behavioral seizures and cortical epileptiform spike frequency, improved passive-avoidance retention, and altered glutamate, GABA and inflammatory/oxidative markers. Nalmefene substantially attenuated the effects but did not fully reverse them, suggesting both opioid-related and other mechanisms.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Models | Two acute seizure models: pentylenetetrazole and penicillin | |
| Seizure activity | Behavioral seizures and cortical spike frequency reduced | Numerical reduction not supplied by the abstract |
| Memory | Passive-avoidance retention improved | |
| Nalmefene challenge | Substantial but incomplete attenuation of effects |
Acute rat seizure models, not clinical epilepsy evidence. The abstract does not provide numerical effect sizes or group-specific seizure counts. Spinorphin results cannot be assigned to all members of the myelopeptide family.
Source for the extracted data ↗ · Checked 2026-10-31
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Acute rat seizure models, not clinical epilepsy evidence. The abstract does not provide numerical effect sizes or group-specific seizure counts. Spinorphin results cannot be assigned to all members of the myelopeptide family.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Primary publication metadata and indexed abstract checked through Europe PMC on 31 October 2026. No unavailable effect sizes inferred.
Recorded source-check date: 2026-10-31. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Torun IE, Baranoglu Kilinc Y, Kilinc E, Ankarali S. Spinorphin Attenuates Acute Experimental Seizures and Associated Neurochemical Alterations: Possible Involvement of Opioid Receptors Neurochemical research 51(6) 2026.
Molekul research summary: https://molekul.io/research/oct31-42900439. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry