An OGP binding protein complex-mimicking peptide hydrogel for dental pulp regeneration
Sha Y, Zhan W, Qin Z, Sun S, Li J, Zong Y, Li M, Jiang F, Liang G, Zhang G · 2026 · Biomaterials 338(Pt B)
Published 2026-10-06. Indexed 2026-10-19.
Reported findings and study design
An engineered OGP-mimetic hydrogel enhanced osteogenic/odontogenic differentiation markers RUNX2, ALP and DSPP in dental-pulp stem cells, without significantly changing proliferation. It also increased mineralized-tissue formation in an ectopic implantation model. The system was designed to protect its peptide cargo and control release.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Dental-pulp differentiation | RUNX2, ALP and DSPP expression increased | Human cells in culture |
| Cell proliferation | No significant change | |
| Mineralized tissue | Increased formation in an ectopic renal-capsule model | Engineered hydrogel; not isolated OGP in patients |
The intervention is an engineered OGP-fragment-mimetic hydrogel, not unmodified OGP. Human cells in culture are not treated patients; the implantation model is not a clinical dental-pulp trial.
Source for the extracted data ↗ · Checked 2026-10-31
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The intervention is an engineered OGP-fragment-mimetic hydrogel, not unmodified OGP. Human cells in culture are not treated patients; the implantation model is not a clinical dental-pulp trial.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Primary publication metadata and indexed abstract checked through Europe PMC on 31 October 2026. No unavailable effect sizes inferred.
Recorded source-check date: 2026-10-31. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Sha Y, Zhan W, Qin Z, Sun S, Li J, Zong Y, Li M, Jiang F, Liang G, Zhang G. An OGP binding protein complex-mimicking peptide hydrogel for dental pulp regeneration Biomaterials 338(Pt B) 2026.
Molekul research summary: https://molekul.io/research/oct31-42863378. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry