Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Konstantinopolsky MA, Chernyakova IV, Kolik LG · 2022 · Bulletin of experimental biology and medicine
Reported findings and study design
Rat morphine-withdrawal model; single IP Selank 0.3 mg/kg versus diazepam 2 mg/kg.
Dose, route and schedule
Single intraperitoneal Selank dose of 0.3 mg/kg; diazepam comparator 2 mg/kg.
Protocol source ↗ · Indexed abstract
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Total withdrawal index reduction | 39.6% Selank versus 49.3% diazepam | |
| Tactile sensitivity threshold | Ninefold versus thirteenfold increase | |
| Convulsions, ptosis and posture disorders | Attenuation reported with Selank | p<0.0001 |
Animal dependence model; no human withdrawal regimen or efficacy is established.
Source for the extracted data ↗ · Checked 2026-10-29
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal and laboratory findings do not establish benefit in people.
- Indexed abstract reviewed; complete methods, sample-size details and adverse-event tables have not been assessed.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Publication metadata and indexed abstract checked through Europe PMC on 28 October 2026; full text not appraised.
Recorded source-check date: 2026-10-28. This date does not imply a completed systematic review.
Citation and original source
Original source: Konstantinopolsky MA, Chernyakova IV, Kolik LG. Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bulletin of experimental biology and medicine 2022.
Molekul research summary: https://molekul.io/research/oct28-36322304. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry