Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.
Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD · 2019 · Bulletin of experimental biology and medicine
Reported findings and study design
Rats exposed to 10% ethanol as sole fluid for 30 weeks; Selank 0.3 mg/kg/day IP for seven days. Object-recognition test and ex-vivo BDNF assays.
Dose, route and schedule
0.3 mg/kg/day intraperitoneally for seven days.
Protocol source ↗ · Indexed abstract
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Object recognition in non-ethanol nine-month-old rats | Improvement reported | p<0.05 |
| Ethanol-withdrawal memory/attention disturbances | Prevention reported | p<0.01 |
| Ethanol-associated BDNF increase | Prevented in hippocampus and frontal cortex | p<0.05 |
No numerical behavioral effect size is supplied. This is normalization of an ethanol-associated BDNF increase, not a claim that Selank universally raises BDNF.
Source for the extracted data ↗ · Checked 2026-10-29
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal and laboratory findings do not establish benefit in people.
- Indexed abstract reviewed; complete methods, sample-size details and adverse-event tables have not been assessed.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Publication metadata and indexed abstract checked through Europe PMC on 28 October 2026; full text not appraised.
Recorded source-check date: 2026-10-28. This date does not imply a completed systematic review.
Citation and original source
Original source: Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bulletin of experimental biology and medicine 2019.
Molekul research summary: https://molekul.io/research/oct28-31625062. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry