Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients.
Fan D, Krishnamurthi R, Harris P, Barber PA, Guan J · 2019 · Annals of clinical and translational neurology (2019); PMID 31019991
Reported findings and study design
In 34 stroke patients, baseline cyclic glycine-proline/IGF-1 ratio was associated with later neurological recovery. Patients were not treated with cGP; this was a biomarker study.
34 patients recruited within 3 days of stroke; 50 age-matched controls without stroke.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Biomarker association | Lower baseline cGP and cGP/IGF-1 ratio in stroke; baseline ratio correlated with day-90 NIHSS and its change | No correlation coefficient or absolute concentration in the indexed abstract |
| Participants | 34 stroke patients; 50 controls | |
| Assessment schedule | Baseline within 3 days; days 7 and 90 |
An association with endogenous cGP does not show that giving cGP or GZK-111 improves recovery.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Observational association is not evidence that CPG administration improves stroke recovery. Small cohort; causal interpretation and external predictive validity remain unresolved.
- Indexed abstract checked; complete methods, tables and independent replication have not been appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original publication metadata and indexed abstract checked via Europe PMC; no full-text appraisal.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.1002/acn3.743
Citation and original source
Original source: Fan D, Krishnamurthi R, Harris P, Barber PA, Guan J. Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients. Annals of clinical and translational neurology (2019); PMID 31019991 2019.
Molekul research summary: https://molekul.io/research/oct17-31019991. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
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