Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1.
Guan J, Gluckman P, Yang P, Krissansen G, Sun X, Zhou Y, Wen J, Phillips G, Shorten PR, McMahon CD, Wake GC, Chan WH, Thomas MF, Ren A, Moon S, Liu DX · 2014 · Scientific reports (2014); PMID 24633053
Study data at a glance
- Participants or experimental model
- Cell culture, mathematical modeling, rat ischemic brain injury and mouse tumor experiments
- Reported results
- The investigators reported context-dependent modulation of IGF-1 activity and modeled altered binding to IGFBP-3. Animal experiments reported improved ischemic recovery and inhibited lymphoma growth.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Multiple experimental systems do not establish a clinical mechanism or treatment benefit. Keep these IGF-1 findings separate from the Russian AMPA/TrkB experiments.
- Indexed abstract checked; complete methods, tables and independent replication have not been appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original publication metadata and indexed abstract checked via Europe PMC; no full-text appraisal.
Recorded source-check date: 2026-10-17. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.1038/srep04388
Citation and original source
Original source: Guan J, Gluckman P, Yang P, Krissansen G, Sun X, Zhou Y, Wen J, Phillips G, Shorten PR, McMahon CD, Wake GC, Chan WH, Thomas MF, Ren A, Moon S, Liu DX. Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1. Scientific reports (2014); PMID 24633053 2014.
Molekul research summary: https://molekul.io/research/oct17-24633053. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry