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NIH deep phenotyping of post-infectious ME/CFS

Walitt B et al. · 2024 · Nature Communications

Indexed 2026-11-12.

Uncontrolled human reportFull text availableSource linked

Reported findings and study design

Reported findings

Exploratory inpatient phenotyping across clinical, immune, autonomic, metabolic and exercise measures.

Dose, route and schedule

Exploratory inpatient phenotyping across clinical, immune, autonomic, metabolic and exercise measures.

Protocol source ↗ · Original source

Results · Original full text
MeasureResultComparison, timing and statistics
Measured differencesThe authors reported differences in selected autonomic, immune and cerebrospinal-fluid measures.
Tilt-table testingNo group differences in rates of orthostatic hypotension, excessive orthostatic tachycardia or symptoms ending the test.

Small, intensively selected cohort. Exploratory signals need independent validation and do not establish a diagnostic test.

Source for these results ↗ · Reviewed 2026-11-12

For research and education. Consult a qualified clinician for medical advice.

Study limitations and source details

Study limitations

  • Small, intensively selected cohort. Exploratory signals need independent validation and do not establish a diagnostic test.

Source access

Exploratory inpatient phenotyping across clinical, immune, autonomic, metabolic and exercise measures.

Source reviewed 2026-11-12.

Open source ↗

DOI: 10.1038/s41467-024-45107-3

Citation and original source

Original source: Walitt B et al.. NIH deep phenotyping of post-infectious ME/CFS Nature Communications 2024.

Molekul research summary: https://molekul.io/research/nih-postinfectious-phenotyping-2024. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

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