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IVIG dose comparison in adults with chronic fatigue syndrome

Vollmer-Conna U et al. · 1997 · American Journal of Medicine

Indexed 2026-11-12.

Randomized trialEnglish abstractSource linked

Reported findings and study design

Reported findings

Double-blind comparison of IVIG at 0.5, 1 or 2 g/kg versus 1% albumin placebo. Three monthly infusions were followed by three months without treatment. Physical, psychological and functional outcomes were assessed.

Dose, route and schedule

Double-blind comparison of IVIG at 0.5, 1 or 2 g/kg versus 1% albumin placebo. Three monthly infusions were followed by three months without treatment. Physical, psychological and functional outcomes were assessed.

Protocol source ↗ · Original article abstract

Results · Original article abstract
MeasureResultComparison, timing and statistics
Clinical outcomesThe trial found no specific benefit from IVIG over placebo at the doses studied.

Historical case definitions and preparations differ across immunoglobulin studies.

Source for these results ↗ · Reviewed 2026-11-12

For research and education. Consult a qualified clinician for medical advice.

Study limitations and source details

Study limitations

  • Historical case definitions and preparations differ across immunoglobulin studies.

Source access

Double-blind comparison of IVIG at 0.5, 1 or 2 g/kg versus 1% albumin placebo. Three monthly infusions were followed by three months without treatment. Physical, psychological and functional outcomes were assessed.

Source reviewed 2026-11-12.

Open source ↗

Citation and original source

Original source: Vollmer-Conna U et al.. IVIG dose comparison in adults with chronic fatigue syndrome American Journal of Medicine 1997.

Molekul research summary: https://molekul.io/research/ivig-dose-cfs-1997. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

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