The drug Hypoxen: a new inhibitor of mitochondrial respiration and dehydrogenases

What does this source report?

Hypoxen reduced phosphorylating and uncoupled respiration, with substrate-dependent concentration thresholds. Malate, glutamate and succinate dehydrogenase activities decreased. This qualifies the claim that it uniformly increases mitochondrial respiration.

Population and setting

Isolated rat liver mitochondria

Evidence type

In vitro

Preparation

See the original report; formulation details require verification.

Source language

Russian; English abstract

Title provenance

Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

• Isolated organelles and experimental concentrations do not establish effects of oral use in humans.
• The translation and Russian paper are the same experiment.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Document format: Journal article

Review depth: Abstract reviewed

Source access and review scope

Indexed or publisher abstract reviewed; full methods and risk of bias not appraised.

Recorded source-check date: 2026-10-04. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.1134/S1062359010040035

Cite and trace this record

Original source: E. A. Kosenko, M. B. Abramova, N. I. Venediktova, I. I. Popova, Yu. G. Kaminskii. The drug Hypoxen: a new inhibitor of mitochondrial respiration and dehydrogenases Izv Akad Nauk Ser Biol. (4):411–416; English translation Biology Bulletin 37:346–350 2010.

Molekul research summary: https://molekul.io/research/hypoxen-mitochondria-2010. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

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